Reactome | arginine + H2O => ornithine + urea [ARG1]

arginine + H2O => ornithine + urea [ARG1]

Stable Identifier

R-HSA-70569

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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arginine + H2O => ornithine + urea [ARG1]

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Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
16141327	Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response Centeno, F, Rodriguez, PC, Mora, A, Christianson, DW, Di Costanzo, L, Ochoa, AC, Sabio, G	Proc Natl Acad Sci U S A	2005
7649538	Molecular basis of phenotypic variation in patients with argininemia Shapira, SK, Matsuda, I, Uchino, T, Lambert, M, Smit, LM, Qureshi, IA, Snyderman, SE, Sansaricq, C, Jakobs, C	Hum Genet	1995