arginine + H2O => ornithine + urea [ARG1]

Stable Identifier
R-HSA-70569
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).

Literature References
PubMed ID Title Journal Year
7649538 Molecular basis of phenotypic variation in patients with argininemia

Uchino, T, Snyderman, SE, Lambert, M, Qureshi, IA, Shapira, SK, Sansaricq, C, Smit, LM, Jakobs, C, Matsuda, I

Hum Genet 1995
16141327 Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response

Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, PC, Ochoa, AC, Centeno, F, Christianson, DW

Proc Natl Acad Sci U S A 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arginase activity of ARG1 trimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored