Reactome | carbamoyl phosphate + ornithine => citrulline + orthophosphate

carbamoyl phosphate + ornithine => citrulline + orthophosphate

Stable Identifier

R-HSA-70560

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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carbamoyl phosphate + ornithine => citrulline + orthophosphate

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Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11237854	Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes Shi, D, Morizono, H, Yu, X, Tong, L, Allewell, NM, Tuchman, M	Biochem J	2001
6372096	Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Horwich, AL, Fenton, WA, Williams, KR, Kalousek, F, Kraus, JP, Doolittle, RF, Konigsberg, W, Rosenberg, LE	Science	1984