Reactome | carbamoyl phosphate + ornithine => citrulline + orthophosphate

carbamoyl phosphate + ornithine => citrulline + orthophosphate

Stable Identifier

R-HSA-70560

Type

Reaction

Species

Homo sapiens

Compartment

mitochondrial matrix

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carbamoyl phosphate + ornithine => citrulline + orthophosphate

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Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
6372096	Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Doolittle, RF, Konigsberg, W, Kalousek, F, Kraus, JP, Williams, KR, Fenton, WA, Horwich, AL, Rosenberg, LE	Science	1984
11237854	Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes Tong, L, Tuchman, M, Allewell, NM, Yu, X, Shi, D, Morizono, H	Biochem J	2001