2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]

Stable Identifier
R-HSA-70555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
ReviewStatus
5/5
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2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'NH4+', 1 molecule of 'HCO3-', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'Carbamoyl phosphate', 1 molecule of 'ADP', and 1 molecule of 'Orthophosphate' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the 'carbamoyl-phosphate synthase (ammonia) activity' of 'carbamoyl-phosphate synthetase I dimer'.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

carbamoyl-phosphate synthase (ammonia) activity of CPS1 [mitochondrial matrix]

Physical Entity
CPS1 [mitochondrial matrix] (Homo sapiens)
Activity
carbamoyl-phosphate synthase (ammonia) activity (GO:0004087)
This event is regulated
Positively by
Regulator
NAcGlu [mitochondrial matrix]
Orthologous Events
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Gallus gallus)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Rattus norvegicus)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Saccharomyces cerevisiae)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Schizosaccharomyces pombe)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2003-06-24)
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