Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PCK1 [cytosol]
Stable Identifier
R-HSA-70495
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphoenolpyruvate carboxykinase 1 (soluble), Phosphoenolpyruvate carboxykinase, cytosolic (GTP), Phosphoenolpyruvate carboxylase, PEPCK-C
Locations in the PathwayBrowser for interactor UniProt:Q16822 PCK2
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PCK1 [cytosol] (Homo sapiens)
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir metabolism (Homo sapiens)
carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)
PCK1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)
PCK1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
PCK1 phosphorylates OA to yield PEP (Homo sapiens)
PCK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis (Homo sapiens)
Expression of PCK1 regulated by NR1H3 (Homo sapiens)
PCK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35558 PCK1
Gene Names
PCK1, PEPCK1
Chain
chain:1-622
Reference Genes
BioGPS Gene:5105 PCK1
COSMIC (genes):PCK1 PCK1
CTD Gene:5105 PCK1
dbSNP Gene:5105 PCK1
ENSEMBL:ENSG00000124253 PCK1
HGNC:8724 PCK1
KEGG:hsa:5105 PCK1
Monarch:5105 PCK1
NCBI Gene:5105 PCK1
OMIM:614168 PCK1
UCSC:P35558 PCK1
Reference Transcript
RefSeq:NM_002591.3 PCK1
Other Identifiers
11726273_a_at
11726274_x_at
11749273_a_at
11750472_a_at
11754614_a_at
16915182
208383_PM_s_at
208383_s_at
33702_f_at
33703_f_at
3890642
3890643
3890644
3890645
3890646
3890647
3890648
3890649
3890650
3890651
3890652
3890653
3890654
3890655
3890656
3890657
3890658
3890659
3890662
3890663
3890664
3890665
3890667
5105
70879_at
80570_at
80604_at
8063590
84670_at
A_23_P210623
A_23_P408249
GE57561
GE581880
GO:0000287
GO:0003824
GO:0004611
GO:0004613
GO:0005525
GO:0005737
GO:0005783
GO:0005829
GO:0005975
GO:0006006
GO:0006094
GO:0006107
GO:0006355
GO:0006629
GO:0009617
GO:0014823
GO:0016301
GO:0016740
GO:0016829
GO:0016831
GO:0017076
GO:0018105
GO:0019003
GO:0019543
GO:0030145
GO:0030154
GO:0031406
GO:0031667
GO:0032496
GO:0032868
GO:0032869
GO:0033993
GO:0042593
GO:0042594
GO:0043226
GO:0043382
GO:0043648
GO:0045944
GO:0046166
GO:0046327
GO:0046872
GO:0046889
GO:0046890
GO:0051365
GO:0070062
GO:0070365
GO:0070741
GO:0071300
GO:0071320
GO:0071332
GO:0071333
GO:0071347
GO:0071356
GO:0071377
GO:0071456
GO:0071474
GO:0071475
GO:0071476
GO:0071477
GO:0071549
GO:0072350
GO:0097403
GO:0106264
GO:0140096
GO:1901135
GO:1904628
GO:1904640
HMNXSV003053295
ILMN_1731948
ILMN_2197381
L05144_at
L12760_s_at
PH_hs_0000250
PH_hs_0012260
TC20000450.hg
g4505638_3p_a_at
Participates
as an output of
Expression of PCK1 regulated by NR1H3 (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)
Inferred To
pck1 [cytosol]
(Danio rerio)
pck1 [cytosol]
(Xenopus tropicalis)
PCK1 [cytosol]
(Bos taurus)
PCK1 [cytosol]
(Canis familiaris)
PCK1 [cytosol]
(Dictyostelium discoideum)
PCK1 [cytosol]
(Drosophila melanogaster)
PCK1 [cytosol]
(Gallus gallus)
PCK1 [cytosol]
(Rattus norvegicus)
PCK1 [cytosol]
(Sus scrofa)
pck-1 [cytosol]
(Caenorhabditis elegans)
Homologues of PCK1 [cytosol]
(Caenorhabditis elegans)
Homologues of PCK1 [cytosol]
(Drosophila melanogaster)
Pepck2 [cytosol]
(Drosophila melanogaster)
pck-3 [cytosol]
(Caenorhabditis elegans)
pck-2 [cytosol]
(Caenorhabditis elegans)
Pck1 [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_002582.3
ENSEMBL
ENST00000319441
,
ENSP00000319814
OpenTargets
ENSG00000124253
ZINC - Substances
PCKGC_HUMAN
ZINC target
P35558
PRO
P35558
GlyGen
P35558
PDB
1KHB
,
1KHE
,
1M51
,
1KHG
,
1KHF
,
2GMV
,
1NHX
HPA
ENSG00000124253-PCK1
Pharos - Targets
P35558
Orphanet
PCK1
ZINC - Predictions - Purchasable
PCKGC_HUMAN
HMDB Protein
HMDBP00892
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16822 PCK2
1
PCK2 [mitochondrial matrix]
(R-HSA-372815)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text