Reactome | ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate

Stable Identifier

R-HSA-70486

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate

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Cytosolic phosphoglycerate kinase complexed with magnesium catalyzes the reversible phosphorylation of 3-phosphoglycerate to form 1,3-bisphosphoglycerate (Huang et al. 1980a, 1980b).

Literature References

PubMed ID	Title	Journal	Year
6771269	Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides. Huang, IY, Rubinfien, E, Yoshida, A	J Biol Chem	1980
7391027	Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence. Huang, IY, Welch, CD, Yoshida, A	J Biol Chem	1980

Participants

Input

Output

Participant Of

hasEvent

Gluconeogenesis

Event Information

Reverse Reaction

1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)

Catalyst Activity

Catalyst Activity

Title

phosphoglycerate kinase activity of PGK complexes [cytosol]

Physical Entity

PGK complexes [cytosol]

Activity

phosphoglycerate kinase activity (0004618)

Orthologous Events

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Caenorhabditis elegans)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Canis familiaris)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Danio rerio)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Dictyostelium discoideum)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Drosophila melanogaster)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Gallus gallus)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Mus musculus)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Plasmodium falciparum)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Rattus norvegicus)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Saccharomyces cerevisiae)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Schizosaccharomyces pombe)

ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Xenopus tropicalis)

Cross References

Rhea

14802

Reviewed

Harris, RA (2008-09-10)

Jassal, B (2015-11-09)

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