Reactome | PGM:Mg2+ isomerise G1P to G6P

PGM:Mg2+ isomerise G1P to G6P

Stable Identifier

R-HSA-70427

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phosphoglucomutase 1 (PGM1) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) also possesses phosphoglucomutase activity (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18927083	Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase Veiga-da-Cunha, M, Vleugels, W, Maliekal, P, Matthijs, G, Van Schaftingen, E	J. Biol. Chem.	2008
7902568	The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination March, RE, Putt, W, Hollyoake, M, Ives, JH, Lovegrove, JU, Hopkinson, DA, Edwards, YH, Whitehouse, DB	Proc Natl Acad Sci U S A	1993
17804405	Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family Maliekal, P, Sokolova, T, Vertommen, D, Veiga-da-Cunha, M, Van Schaftingen, E	J Biol Chem	2007