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HK2 [cytosol]
Stable Identifier
R-HSA-70378
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hexokinase 2, hexokinase type 2, hexokinase muscle form, HXK2_HUMAN, Hexokinase, type II , HK II, Muscle form hexokinase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)
glucokinase and hexokinases [cytosol] (Homo sapiens)
HK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52789 HK2
Gene Names
HK2
Chain
chain:1-917
Reference Genes
BioGPS Gene:3099 HK2
COSMIC (genes):HK2 HK2
CTD Gene:3099 HK2
dbSNP Gene:3099 HK2
ENSEMBL:ENSG00000159399 HK2
HGNC:4923 HK2
KEGG:hsa:3099 HK2
Monarch:3099 HK2
NCBI Gene:3099 HK2
OMIM:601125 HK2
UCSC:P52789 HK2
Reference Transcript
RefSeq:NM_000189.4 HK2
Other Identifiers
11749099_a_at
11756138_a_at
16881838
202934_PM_at
202934_at
2489546
2489547
2489548
2489549
2489556
2489570
2489571
2489572
2489573
2489575
2489576
2489577
2489579
2489580
2489584
2489585
2489588
2489589
2489592
2489595
2489596
2489597
2489599
2489601
2489602
2489603
2489604
2489605
2489607
2489659
3099
4013645
4013646
4013673
4013675
4013677
4013679
4013683
4013689
4013693
4013703
4013705
4013707
4013711
40964_at
50230_at
8042942
A_23_P398460
GE79212
GE87081
GO:0001666
GO:0001678
GO:0002931
GO:0003824
GO:0004340
GO:0004396
GO:0005515
GO:0005524
GO:0005536
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005975
GO:0006002
GO:0006006
GO:0006091
GO:0006096
GO:0007005
GO:0007595
GO:0008637
GO:0008865
GO:0016020
GO:0016301
GO:0016529
GO:0016740
GO:0016773
GO:0019318
GO:0035795
GO:0043226
GO:0043231
GO:0045766
GO:0046324
GO:0046835
GO:0051156
GO:0055086
GO:0061024
GO:0061621
GO:0072655
GO:0072656
GO:1901135
GO:1904925
GO:1990830
GO:2000378
HMNXSV003045287
Hs.198427.0.S3_3p_at
ILMN_1723486
ILMN_2156172
PH_hs_0030058
TC02000466.hg
Z46376_rna1_at
Participates
as a member of
glucokinase and hexokinases [cytosol] (Homo sapiens)
Inferred To
HK1 [cytosol]
(Plasmodium falciparum)
HK1 [cytosol]
(Saccharomyces cerevisiae)
HK1 [cytosol]
(Schizosaccharomyces pombe)
Hex-A [cytosol]
(Drosophila melanogaster)
hxk-1 [cytosol]
(Caenorhabditis elegans)
hkdc1 [cytosol]
(Xenopus tropicalis)
HK2 [cytosol]
(Bos taurus)
HK2 [cytosol]
(Canis familiaris)
HK2 [cytosol]
(Gallus gallus)
HK2 [cytosol]
(Mus musculus)
HK2 [cytosol]
(Rattus norvegicus)
HK2 [cytosol]
(Sus scrofa)
hk2 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_000180.2
ENSEMBL
ENSP00000290573
,
ENST00000290573
OpenTargets
ENSG00000159399
HPA
ENSG00000159399-HK2
ZINC - Substances
HXK2_HUMAN
ZINC target
P52789
PRO
P52789
Pharos - Targets
P52789
GlyGen
P52789
ZINC - Predictions - Purchasable
HXK2_HUMAN
HMDB Protein
HMDBP00213
PDB
5HG1
,
5HEX
,
2NZT
,
5HFU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
SRC-1 [plasma membrane]
(R-MMU-65043)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
SRC [cytosol]
(R-MMU-9628701)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.602
4
UniProt:Q9NQ88 TIGAR
1
TIGAR [cytosol]
(R-HSA-5628829)
0.524
3
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