Reactome | GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal

GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal

Stable Identifier

R-HSA-70361

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose

ReviewStatus

5/5

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GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal

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Cytosolic galactose-1-phosphate uridylyltransferase (GALT) catalyzes the reaction of alpha-D-galactose 1-phosphate and UDP glucose to form D-glucose 1-phosphate and UDP galactose (Reichardt & Woo 1991).

Literature References

PubMed ID	Title	Journal	Year
2011574	Molecular basis of galactosemia: mutations and polymorphisms in the gene encoding human galactose-1-phosphate uridylyltransferase Woo, SL, Reichardt, JK	Proc. Natl. Acad. Sci. U.S.A.	1991
1897530	Molecular characterization of two galactosemia mutations: correlation of mutations with highly conserved domains in galactose-1-phosphate uridyl transferase Woo, SL, Reichardt, JK, Packman, S	Am J Hum Genet	1991