PGM:Mg2+ isomerise G6P to G1P

Stable Identifier
Homo sapiens
alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate
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Cytosolic phosphoglucomutase (PGM) catalyses the reversible conversion of glucose 6-phosphate (G6P) to glucose 1-phosphate (G1P) (Drago et al. 1991). Two PGM isoenzymes, both monomers, have been identified which both require Mg2+ as cofactor. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity (Maliekal et al. 2007) and its primary physiological in normal tissues in vivo is not clear. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) also possesses phosphoglucomutase activity (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008).

Literature References
PubMed ID Title Journal Year
7902568 The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination

Lovegrove, JU, Whitehouse, DB, Edwards, YH, Hopkinson, DA, March, RE, Ives, JH, Hollyoake, M, Putt, W

Proc Natl Acad Sci U S A 1993
18927083 Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase

Maliekal, P, Matthijs, G, Vleugels, W, Veiga-da-Cunha, M, Van Schaftingen, E

J. Biol. Chem. 2008
17804405 Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Maliekal, P, Veiga-da-Cunha, M, Sokolova, T, Van Schaftingen, E, Vertommen, D

J Biol Chem 2007
1840235 Antigenic analysis of the major human phosphoglucomutase isozymes: PGM1, PGM2, PGM3 and PGM4

Whitehouse, DB, Hopkinson, DA, Westwood, SA, Drago, GA

Ann Hum Genet 1991
8257433 Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon

Edwards, YH, Whitehouse, DB, Hopkinson, DA, Ives, JH, Hollyoake, M, Putt, W

Biochem J 1993
Event Information
Catalyst Activity

phosphoglucomutase activity of PGM:Mg2+ [cytosol]

Orthologous Events
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