Transcriptional activation of cell cycle inhibitor p21

Stable Identifier
R-HSA-69895
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transcriptional activation of cell cycle inhibitor p21
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Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).
Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

Tokino, T, el-Deiry, WS, Kinzler, KW, Vogelstein, B, Lin, D, Mercer, WE, Parsons, R, Trent, JM, Velculescu, VE, Levy, DB

Cell 1993
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Orthologous Events
Transcriptional activation of cell cycle inhibitor p21 (Bos taurus)
Transcriptional activation of cell cycle inhibitor p21 (Canis familiaris)
Transcriptional activation of cell cycle inhibitor p21 (Mus musculus)
Transcriptional activation of cell cycle inhibitor p21 (Rattus norvegicus)
Transcriptional activation of cell cycle inhibitor p21 (Sus scrofa)
Transcriptional activation of cell cycle inhibitor p21 (Xenopus tropicalis)
Cross References
BioModels Database
Created
Khanna, KK  (2003-06-05)
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