Transcriptional activation of cell cycle inhibitor p21

Stable Identifier
R-HSA-69895
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcriptional activation of cell cycle inhibitor p21
Click the image above or here to open this pathway in the Pathway Browser

Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

Tokino, T, el-Deiry, WS, Kinzler, KW, Vogelstein, B, Lin, D, Mercer, WE, Parsons, R, Trent, JM, Velculescu, VE, Levy, DB

Cell 1993
Participants
Events
Participates
as an event of
Orthologous Events
Transcriptional activation of cell cycle inhibitor p21 (Bos taurus)
Transcriptional activation of cell cycle inhibitor p21 (Canis familiaris)
Transcriptional activation of cell cycle inhibitor p21 (Danio rerio)
Transcriptional activation of cell cycle inhibitor p21 (Mus musculus)
Transcriptional activation of cell cycle inhibitor p21 (Rattus norvegicus)
Transcriptional activation of cell cycle inhibitor p21 (Sus scrofa)
Cross References
BioModels Database
Created
Khanna, KK  (2003-06-05)
Cite Us!