Reactome | Transcriptional activation of cell cycle inhibitor p21

Transcriptional activation of cell cycle inhibitor p21

Stable Identifier

R-HSA-69895

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Transcriptional activation of p53 responsive genes (Homo sapiens)
        
        Transcriptional activation of cell cycle inhibitor p21 (Homo sapiens)

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Transcriptional activation of cell cycle inhibitor p21

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Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).

Literature References

PubMed ID	Title	Journal	Year
8242752	WAF1, a potential mediator of p53 tumor suppression. el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B	Cell	1993