Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes

Stable Identifier
R-HSA-69756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
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At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'G2/M transition protein' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phospho-G2/M transition protein' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'cyclin-dependent protein kinase activity' of 'Cyclin A2:Cdc2'.

Literature References
PubMed ID Title Journal Year
7969176 Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

Xu, M, Sheppard, KA, Peng, CY, Yee, AS, Piwnica-Worms, H

Mol Cell Biol 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA2:p-T161-CDK1 [nucleoplasm]
Physical Entity
CCNA2:p-T161-CDK1 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
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