p53-Dependent G1/S DNA damage checkpoint

Stable Identifier
R-HSA-69580
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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p53-Dependent G1/S DNA damage checkpoint
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The arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbitz et al, 1992). P53 is rapidly induced in response to damaged DNA. A number of kinases, phosphatases, histone acetylases and ubiquitin-conjugating enzymes regulate the stability as well as transcriptional activity of p53 after DNA damage.
Literature References
PubMed ID Title Journal Year
1323840 Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Kastan, MB, Kuerbitz, SJ, Plunkett, BS, Walsh, WV

Proc Natl Acad Sci U S A 1992
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Orthologous Events
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Authored
Khanna, KK  (2003-06-05)
Created
Khanna, KK  (2003-06-05)
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