Reactome | Transcriptional activation of p53 responsive genes

Transcriptional activation of p53 responsive genes

Stable Identifier

R-HSA-69560

Type

Pathway

Species

Homo sapiens

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Transcriptional activation of p53 responsive genes

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p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration and cell cycle arrest at the G1/S transition. Mice with a homozygous deletion of p21 gene are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995).

Literature References

PubMed ID	Title	Journal	Year
8242752	WAF1, a potential mediator of p53 tumor suppression. el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B	Cell	1993
8259214	p21 is a universal inhibitor of cyclin kinases. Xiong, Y, Hannon, GJ, Zhang, H, Casso, D, Kobayashi, R, Beach, D	Nature	1994
8242751	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Harper, JW, Adami, GR, Wei, N, Keyomarsi, K, Elledge, SJ	Cell	1993
7664346	Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Deng, C, Zhang, P, Harper, JW, Elledge, SJ, Leder, P	Cell	1995