Transcriptional activation of p53 responsive genes

Stable Identifier
Homo sapiens
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p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration and cell cycle arrest at the G1/S transition. Mice with a homozygous deletion of p21 gene are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995).

Literature References
PubMed ID Title Journal Year
8259214 p21 is a universal inhibitor of cyclin kinases.

Xiong, Y, Hannon, GJ, Kobayashi, R, Casso, D, Beach, D, Zhang, H

Nature 1994
8242752 WAF1, a potential mediator of p53 tumor suppression.

Tokino, T, el-Deiry, WS, Kinzler, KW, Vogelstein, B, Lin, D, Mercer, WE, Parsons, R, Trent, JM, Velculescu, VE, Levy, DB

Cell 1993
8242751 The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Keyomarsi, K, Elledge, SJ, Adami, GR, Wei, N, Harper, JW

Cell 1993
7664346 Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.

Zhang, P, Elledge, SJ, Deng, C, Leder, P, Harper, JW

Cell 1995
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