Reactome | CDK7 [nucleoplasm]

CDK7 [nucleoplasm]

Stable Identifier

R-HSA-69218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdk7, Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1), Cell division protein kinase 7 , CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, P39 Mo15, STK1, CAK1

Locations in the PathwayBrowser for interactor UniProt:P32780%20GTF2H1

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External Reference Information

External Reference

UniProt:P50613 CDK7

Gene Names

CDK7, CAK, CAK1, CDKN7, MO15, STK1

Chain

initiator methionine:, chain:2-346

Reference Genes

BioGPS Gene:1022 CDK7

COSMIC (genes):CDK7 CDK7

CTD Gene:1022 CDK7

dbSNP Gene:1022 CDK7

ENSEMBL:ENSG00000134058 CDK7

ENSEMBL_homo_sapiens_GENE:ENSG00000134058.12 CDK7

ENSEMBL_homo_sapiens_GENE:ENSG00000277273.5 CDK7

HGNC:1778 CDK7

KEGG Gene (Homo sapiens):1022 CDK7

Monarch:1022 CDK7

NCBI Gene:1022 CDK7

OMIM:601955 CDK7

UCSC:P50613 CDK7

Reference Transcript

Other Identifiers

1022

11717845_a_at

16985637

1969_s_at

211297_PM_s_at

211297_s_at

2813483

2813484

2813486

2813490

2813492

2813493

2813498

2813499

2813500

2813503

2813505

2813506

2813507

2813508

33317_at

8105862

8177462

A_23_P133585

GE79229

GO:0000079

GO:0000166

GO:0000278

GO:0000439

GO:0001650

GO:0001673

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005675

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006281

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006367

GO:0006468

GO:0006974

GO:0007049

GO:0008094

GO:0008353

GO:0016073

GO:0016301

GO:0016310

GO:0016740

GO:0019907

GO:0036211

GO:0042795

GO:0043226

GO:0045944

GO:0048471

GO:0050821

GO:0051301

GO:0051726

GO:0070516

GO:0070985

GO:0106310

GO:0140096

GO:0140097

GO:0140657

GO:2000045

HMNXSV003054204

ILMN_1778917

L20320_at

PH_hs_0027953

TC05000301.hg

g348242_3p_a_at

Participates

as an input of

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)

as a component of

Inferred To

Ghost homologue of CDK7 [nucleoplasm] (Plasmodium falciparum)

CDK7 [nucleoplasm] (Bos taurus)

CDK7 [nucleoplasm] (Caenorhabditis elegans)

CDK7 [nucleoplasm] (Canis familiaris)

CDK7 [nucleoplasm] (Danio rerio)

CDK7 [nucleoplasm] (Dictyostelium discoideum)

CDK7 [nucleoplasm] (Drosophila melanogaster)

CDK7 [nucleoplasm] (Gallus gallus)

CDK7 [nucleoplasm] (Mus musculus)

CDK7 [nucleoplasm] (Rattus norvegicus)

CDK7 [nucleoplasm] (Saccharomyces cerevisiae)

CDK7 [nucleoplasm] (Schizosaccharomyces pombe)

CDK7 [nucleoplasm] (Sus scrofa)

CDK7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001310999.1, NP_001311006.1, NP_001790.1, NP_001311000.1, NP_001310998.1

ZINC - World Drugs

CDK7_HUMAN

Guide to Pharmacology - Targets

1979

OpenTargets

ENSG00000134058

ZINC - FDA approved

CDK7_HUMAN

ZINC - Substances

CDK7_HUMAN

ZINC target

P50613

ZINC - Biogenic

CDK7_HUMAN

PRO

P50613

PDB

6XBZ, 7B5Q, 8ORM, 8BYQ, 7EGB, 6O9L, 7ENA, 1UA2, 8BVW, 8P4Z, 7NVR, 8GXQ, 7EGC, 7ENC, 8GXS, 8P6V, 7B5O, 7LBM, 8P6Y, 6XD3

ZINC - Investigational

CDK7_HUMAN

IntEnz

2.7.11.23

HPA

ENSG00000134058-CDK7

GeneCards

P50613

Ensembl

ENST00000256443, ENSG00000277273, ENSP00000256443, ENST00000615305, ENSG00000134058, ENSP00000479116

Pharos - Targets

P50613

ZINC - Predictions - Purchasable

CDK7_HUMAN

HMDB Protein

HMDBP01388

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.932	15
UniProt:P51948 MNAT1	1	MNAT1 [nucleoplasm] (R-HSA-59012)	0.823	11
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.763	7
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.745	7
UniProt:P18074 ERCC2	2	ERCC2 [cytosol] (R-HSA-2564770) ERCC2 [nucleoplasm] (R-HSA-67443)	0.745	7
UniProt:Q6ZYL4 GTF2H5	1	GTF2H5 [nucleoplasm] (R-HSA-5688446)	0.745	7
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.713	3
UniProt:Q13888 GTF2H2	1	GTF2H2 [nucleoplasm] (R-HSA-65914)	0.671	9
UniProt:Q13889 GTF2H3	1	GTF2H3 [nucleoplasm] (R-HSA-65916)	0.671	6
UniProt:P28715 ERCC5	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.671	6
UniProt:Q92759 GTF2H4	1	GTF2H4 [nucleoplasm] (R-HSA-65918)	0.671	6
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.59	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.59	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:Q6P1K8 T2H2L			0.527	2
UniProt:P46013 KI67			0.483	3

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