Leading Strand Synthesis

Stable Identifier
R-HSA-69109
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Leading Strand Synthesis
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The processive complex is responsible for synthesizing at least 5-10 kb of DNA in a continuous manner during leading strand synthesis. The incorporation of nucleotides by pol delta is quite accurate. However, incorporation of an incorrect nucleotide does occur occasionally. Misincorporated nucleotides are removed by the 3' to 5' exonucleolytic proofreading capability of pol delta.
Literature References
PubMed ID Title Journal Year
7378348 Purification of deoxyribonucleic acid polymerase delta from calf thymus: partial characterization of physical properties.

So, AG, Downey, KM, Tan, CK, Lee, MY

Biochemistry 1980
2175912 Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system.

Hurwitz, J, Matsumoto, T, Eki, T

Proc Natl Acad Sci U S A 1991
9191022 DNA polymerase delta, an essential enzyme for DNA transactions.

Hubscher, U, Hindges, R

Biol Chem 1997
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Orthologous Events
Leading Strand Synthesis (Bos taurus)
Leading Strand Synthesis (Caenorhabditis elegans)
Leading Strand Synthesis (Canis familiaris)
Leading Strand Synthesis (Dictyostelium discoideum)
Leading Strand Synthesis (Drosophila melanogaster)
Leading Strand Synthesis (Gallus gallus)
Leading Strand Synthesis (Mus musculus)
Leading Strand Synthesis (Plasmodium falciparum)
Leading Strand Synthesis (Rattus norvegicus)
Leading Strand Synthesis (Saccharomyces cerevisiae)
Leading Strand Synthesis (Schizosaccharomyces pombe)
Leading Strand Synthesis (Sus scrofa)
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