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Polymerase switching
Stable Identifier
R-HSA-69091
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
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After the primers are synthesized, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA.
Literature References
PubMed ID
Title
Journal
Year
1967833
Functions of replication factor C and proliferating-cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4.
Stillman, B
,
Tsurimoto, T
Proc Natl Acad Sci U S A
1990
1670772
Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta.
Hurwitz, J
,
Kwong, AD
,
Pan, ZQ
,
Lee, SH
J Biol Chem
1991
1671046
Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis.
Stillman, B
,
Tsurimoto, T
J Biol Chem
1991
Participants
Events
RFC binding displaces Pol Alpha
(Homo sapiens)
Loading of PCNA - Sliding Clamp Formation
(Homo sapiens)
RFC dissociates after sliding clamp formation
(Homo sapiens)
Formation of Processive Complex
(Homo sapiens)
Participates
as an event of
Leading Strand Synthesis (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
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Polymerase switching (Schizosaccharomyces pombe)
Polymerase switching (Sus scrofa)
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