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RFC dissociates after sliding clamp formation
Stable Identifier
R-HSA-69068
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
It is assumed that, as shown for generic DNA replication (Podust et al. 1998), the RFC complex dissociates from PCNA following sliding clamp formation at the telomere, and the DNA toroid alone tethers pol delta to the DNA.
Literature References
PubMed ID
Title
Journal
Year
9822671
Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA.
Podust, VN
,
Tiwari, N
,
Stephan, S
J Biol Chem
1998
Participants
Input
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm]
(Homo sapiens)
Output
RFC Heteropentamer [nucleoplasm]
(Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Polymerase switching (Homo sapiens)
Orthologous Events
RFC dissociates after sliding clamp formation (Bos taurus)
RFC dissociates after sliding clamp formation (Caenorhabditis elegans)
RFC dissociates after sliding clamp formation (Canis familiaris)
RFC dissociates after sliding clamp formation (Dictyostelium discoideum)
RFC dissociates after sliding clamp formation (Drosophila melanogaster)
RFC dissociates after sliding clamp formation (Gallus gallus)
RFC dissociates after sliding clamp formation (Mus musculus)
RFC dissociates after sliding clamp formation (Plasmodium falciparum)
RFC dissociates after sliding clamp formation (Rattus norvegicus)
RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)
RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)
RFC dissociates after sliding clamp formation (Sus scrofa)
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