Phosphorylated Orc1 is ubiquitinated while still associated with chromatin

Stable Identifier
R-HSA-68946
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
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ORC1 is ubiquitinated by the SKP2-containing ubiquitin ligase complex and targeted for proteasome-mediated degradation, which may play an important role in the maintenace of ploidy. While the ORC1 region phosphorylated by the CCNA:CDK1 complex is involved in the interaction with SKP2, phosphorylation may not be a pre-requisite for ORC1 ubiquitination (Mendez et al. 2002).

Literature References
PubMed ID Title Journal Year
11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

Hidaka, M, Tansey, WP, Zou-Yang, XH, Mendez, J, Stillman, B, Kim, SY

Mol Cell 2002
Participants
Input
Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of SCF(SKP2) complex [nucleoplasm]

Physical Entity
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Danio rerio)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Xenopus tropicalis)
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