Phosphorylated Orc1 is ubiquitinated while still associated with chromatin

Stable Identifier
R-HSA-68946
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ORC1 is ubiquitinated by the SKP2-containing ubiquitin ligase complex and targeted for proteasome-mediated degradation, which may play an important role in the maintenace of ploidy. While the ORC1 region phosphorylated by the CCNA:CDK1 complex is involved in the interaction with SKP2, phosphorylation may not be a pre-requisite for ORC1 ubiquitination (Mendez et al. 2002).

Literature References
PubMed ID Title Journal Year
11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

Mendez, J, Zou-Yang, XH, Kim, SY, Hidaka, M, Tansey, WP, Stillman, B

Mol Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SCF(SKP2) complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events