Reactome | PSMD14 [cytosol]

PSMD14 [cytosol]

Stable Identifier

R-HSA-68722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

26S proteasome-associated pad1 homolog, RPN11, 26S proteasome regulatory subunit RPN11

Locations in the PathwayBrowser for interactor UniProt:O00232 PSMD12

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External Reference Information

External Reference

UniProt:O00487 PSMD14

Gene Names

PSMD14, POH1

Chain

chain:1-310

Reference Genes

BioGPS Gene:10213 PSMD14

COSMIC (genes):PSMD14 PSMD14

CTD Gene:10213 PSMD14

dbSNP Gene:10213 PSMD14

ENSEMBL:ENSG00000115233 PSMD14

HGNC:16889 PSMD14

KEGG Gene (Homo sapiens):10213 PSMD14

Monarch:10213 PSMD14

NCBI Gene:10213 PSMD14

OMIM:607173 PSMD14

UCSC:O00487 PSMD14

Reference Transcript

RefSeq:NM_005805.5 PSMD14

Other Identifiers

0000430148

10213

11733918_a_at

11744362_a_at

16886919

212296_PM_at

212296_at

2512702

2512703

2512704

2512705

2512708

2512709

2512717

2512718

2512720

2512721

2512731

2512733

2512735

2512744

2512746

2512747

33247_at

43809_at

8045946

A_23_P165691

GE59512

GO:0000502

GO:0000724

GO:0003674

GO:0004843

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006303

GO:0006464

GO:0006508

GO:0006511

GO:0006950

GO:0006974

GO:0008150

GO:0008233

GO:0008237

GO:0008541

GO:0009056

GO:0010950

GO:0016579

GO:0016787

GO:0022624

GO:0030234

GO:0031410

GO:0031597

GO:0032991

GO:0034641

GO:0034774

GO:0043161

GO:0043167

GO:0043226

GO:0045471

GO:0046872

GO:0061133

GO:0061136

GO:0061578

GO:0070122

GO:0070536

GO:0070628

GO:0140492

GO:1904813

HMNXSV003017627

Hs.178761.0.S1_3p_at

ILMN_1737396

PH_hs_0010617

TC02000970.hg

U86782_at

Participates

as a component of

26S proteasome [cytosol] (Homo sapiens)

Other forms of this molecule

PSMD14 [secretory granule lumen]

PSMD14 [extracellular region]

PSMD14 [ficolin-1-rich granule lumen]

PSMD14 [nucleoplasm]

Inferred To

Psmd14 [cytosol] (Mus musculus)

Psmd14 [cytosol] (Rattus norvegicus)

rpn11 [cytosol] (Schizosaccharomyces pombe)

psmd14 [cytosol] (Danio rerio)

psmd14 [cytosol] (Xenopus tropicalis)

Rpn11 [cytosol] (Drosophila melanogaster)

psmD14 [cytosol] (Dictyostelium discoideum)

PSMD14 [cytosol] (Bos taurus)

PSMD14 [cytosol] (Canis familiaris)

PSMD14 [cytosol] (Gallus gallus)

PSMD14 [cytosol] (Plasmodium falciparum)

PSMD14 [cytosol] (Sus scrofa)

rpn-11 [cytosol] (Caenorhabditis elegans)

RPN11 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_005796.1

Guide to Pharmacology - Targets

2410

OpenTargets

ENSG00000115233

GeneCards

O00487

HPA

ENSG00000115233-PSMD14

Ensembl

ENSG00000115233, ENST00000409682, ENSP00000386541

PRO

O00487

Pharos - Targets

O00487

PDB

5GJR, 5VHS, 6MSJ, 5T0H, 5GJQ, 5T0G, 6MSH, 6WJD, 5LN3, 5M32, 6MSG, 6MSE, 5VHH, 5T0C, 5VHI, 5VFT, 6MSD, 5VFU, 5VHF, 5L4K, 6MSB, 5VFS, 5VFR, 5VFQ, 5T0J, 5VGZ, 5T0I, 6WJN, 6MSK, 5VFP

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.874	14
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.718	6
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.688	3
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.669	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.667	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q96EN9 REX1B			0.564	2
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.564	2
UniProt:O75832 PSMD10	2	PSMD10 [nucleoplasm] (R-HSA-174322) PSMD10 [cytosol] (R-HSA-68788)	0.564	2
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.564	3
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.564	2
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.564	2
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.564	2
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.528	2
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.527	2

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