Reactome | The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1

The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1

Stable Identifier

R-HSA-68712

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1

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At the beginning of this reaction, 1 molecule of 'ubiquitin', and 1 molecule of 'Cdt1:geminin' are present. At the end of this reaction, 1 molecule of 'geminin:ubiquitin complex', and 1 molecule of 'Cdt1' are present.

This reaction takes place in the 'cytosol'.

Literature References

PubMed ID	Title	Journal	Year
9635433	Geminin, an inhibitor of DNA replication, is degraded during mitosis. McGarry, TJ, Kirschner, MW	Cell	1998
11125146	Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Cvetic, C, Walter, JC, Wohlschlegel, JA, Dwyer, BT, Dutta, A, Dhar, SK	Science	2000