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ORC5 binds ORC2:ORC3
Stable Identifier
R-HSA-68603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
ORC5 binds ORC2:ORC3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ORC5 forms a heterotrimer with ORC2 and ORC3. ATP is not required for the formation of this complex nor for its maintenance (Ranjan and Gossen 2006; Siddiqui and Stillman 2007).
Literature References
PubMed ID
Title
Journal
Year
16549788
A structural role for ATP in the formation and stability of the human origin recognition complex
Gossen, M
,
Ranjan, A
Proc Natl Acad Sci U S A
2006
17716973
ATP-dependent assembly of the human origin recognition complex
Siddiqui, K
,
Stillman, B
J Biol Chem
2007
Participants
Input
ORC2:ORC3 [nucleoplasm]
(Homo sapiens)
ORC5 [nucleoplasm]
(Homo sapiens)
Output
ORC2:ORC3:ORC5 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Orthologous Events
ORC5 binds ORC2:ORC3 (Bos taurus)
ORC5 binds ORC2:ORC3 (Canis familiaris)
ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)
ORC5 binds ORC2:ORC3 (Drosophila melanogaster)
ORC5 binds ORC2:ORC3 (Gallus gallus)
ORC5 binds ORC2:ORC3 (Mus musculus)
ORC5 binds ORC2:ORC3 (Rattus norvegicus)
ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)
ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)
ORC5 binds ORC2:ORC3 (Sus scrofa)
ORC5 binds ORC2:ORC3 (Xenopus tropicalis)
Authored
O'Donnell, M (2003-06-05)
Davey, MJ (2003-06-05)
Created
O'Donnell, M (2003-06-05)
Davey, MJ (2003-06-05)
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