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ORC2 binds ORC3
Stable Identifier
R-HSA-68595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
ORC2 binds ORC3 (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ORC2 forms a heterodimer with ORC3, which is a prerequisite for the association of other ORC subunits (Ranjan and Gossen 2006).
Literature References
PubMed ID
Title
Journal
Year
16549788
A structural role for ATP in the formation and stability of the human origin recognition complex
Gossen, M
,
Ranjan, A
Proc Natl Acad Sci U S A
2006
Participants
Input
ORC2 [nucleoplasm]
(Homo sapiens)
ORC3 [nucleoplasm]
(Homo sapiens)
Output
ORC2:ORC3 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Orthologous Events
ORC2 binds ORC3 (Bos taurus)
ORC2 binds ORC3 (Canis familiaris)
ORC2 binds ORC3 (Dictyostelium discoideum)
ORC2 binds ORC3 (Drosophila melanogaster)
ORC2 binds ORC3 (Gallus gallus)
ORC2 binds ORC3 (Mus musculus)
ORC2 binds ORC3 (Rattus norvegicus)
ORC2 binds ORC3 (Saccharomyces cerevisiae)
ORC2 binds ORC3 (Schizosaccharomyces pombe)
ORC2 binds ORC3 (Sus scrofa)
ORC2 binds ORC3 (Xenopus tropicalis)
Authored
O'Donnell, M (2003-06-05)
Davey, MJ (2003-06-05)
Created
O'Donnell, M (2003-06-05)
Davey, MJ (2003-06-05)
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