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ORC4 [nucleoplasm]
Stable Identifier
R-HSA-68519
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Orc4, Origin recognition complex subunit 4
Icon
Locations in the PathwayBrowser for interactor UniProt:P15884%20TCF4
Expand all
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(2-5) complex (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43929 ORC4
Gene Names
ORC4, ORC4L
Chain
chain:1-436
Reference Genes
BioGPS Gene:5000 ORC4
COSMIC (genes):ORC4 ORC4
CTD Gene:5000 ORC4
dbSNP Gene:5000 ORC4
ENSEMBL:ENSG00000115947 ORC4
ENSEMBL_homo_sapiens_GENE:ENSG00000115947.14 ORC4
HGNC:8490 ORC4
KEGG Gene (Homo sapiens):5000 ORC4
Monarch:5000 ORC4
NCBI Gene:5000 ORC4
OMIM:603056 ORC4
UCSC:O43929 ORC4
Reference Transcript
RefSeq:NM_001190879.2 ORC4
RefSeq:XM_017004227.1 ORC4
RefSeq:NM_001190882.2 ORC4
RefSeq:NM_181741.3 ORC4
RefSeq:XM_017004226.1 ORC4
RefSeq:NM_001190881.2 ORC4
RefSeq:XM_011511255.2 ORC4
RefSeq:NM_002552.4 ORC4
RefSeq:NM_181742.3 ORC4
Other Identifiers
11730783_a_at
11730784_x_at
11744978_a_at
16903427
203351_PM_s_at
203351_s_at
203352_PM_at
203352_at
2580297
2580299
2580301
2580302
2580303
2580305
2580306
2580307
2580308
2580312
2580313
2580315
2580316
2580319
2580320
2580323
2580325
2580327
2580329
2580330
2580334
2580335
2580336
2580337
2580339
2580343
2580344
2580345
36481_at
5000
8055645
A_23_P131149
A_32_P141612
GE61725
GO:0000166
GO:0000228
GO:0000781
GO:0000808
GO:0000910
GO:0003677
GO:0003688
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005664
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006260
GO:0006270
GO:0016787
GO:0016887
GO:0022414
GO:0040038
GO:0043226
GO:0051258
GO:0065003
GO:0140013
GO:0140657
HMNXSV003017417
ILMN_1740083
PH_hs_0025726
PH_hs_0036013
TC02002408.hg
g2906225_3p_a_at
g4505522_3p_at
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
as an input of
Formation of ORC(2-5) complex (Homo sapiens)
Inferred To
orc4 [nucleoplasm]
(Xenopus tropicalis)
ORC4 [nucleoplasm]
(Bos taurus)
ORC4 [nucleoplasm]
(Canis familiaris)
ORC4 [nucleoplasm]
(Dictyostelium discoideum)
ORC4 [nucleoplasm]
(Gallus gallus)
ORC4 [nucleoplasm]
(Mus musculus)
ORC4 [nucleoplasm]
(Rattus norvegicus)
ORC4 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC4 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC4 [nucleoplasm]
(Sus scrofa)
orc-4 [nucleoplasm]
(Caenorhabditis elegans)
Orc4 [nucleoplasm]
(Drosophila melanogaster)
fc50c03 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_016859716.1
,
NP_859526.1
,
NP_002543.2
,
XP_016859715.1
,
NP_001177811.1
,
NP_859525.1
,
NP_001177808.1
,
NP_001177810.1
,
XP_011509557.1
OpenTargets
ENSG00000115947
HPA
ENSG00000115947-ORC4
GeneCards
O43929
Ensembl
ENST00000540442
,
ENST00000264169
,
ENSP00000441953
,
ENSG00000115947
,
ENST00000535373
,
ENST00000392857
,
ENST00000536575
,
ENSP00000264169
,
ENSP00000441502
,
ENSP00000376597
,
ENSP00000438326
PRO
O43929
Pharos - Targets
O43929
Orphanet
19834
PDB
7JPQ
,
7JPP
,
7JPS
,
7CTE
,
7JPR
,
7JPO
,
5UJM
,
7CTF
,
5UJ7
,
7CTG
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.813
12
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.737
8
UniProt:Q9Y5N6 ORC6
4
ORC6 [nucleoplasm]
(R-HSA-68539)
ORC6 [cytosol]
(R-HSA-9734663)
p-T195-ORC6 [cytosol]
(R-HSA-9734682)
p-T195-ORC6 [nucleoplasm]
(R-HSA-9734715)
0.607
2
UniProt:Q7LG56 RRM2B
1
RRM2B [cytosol]
(R-HSA-111792)
0.601
4
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.59
2
UniProt:Q9UBD5 ORC3
1
ORC3 [nucleoplasm]
(R-HSA-68513)
0.59
12
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q92781 RDH5
6
RDH5 V177G [endoplasmic reticulum membrane]
(R-HSA-2471929)
RDH5 A294P [endoplasmic reticulum membrane]
(R-HSA-2471966)
RDH5 G238W [endoplasmic reticulum membrane]
(R-HSA-2471938)
RDH5 R157W [endoplasmic reticulum membrane]
(R-HSA-2471923)
RDH5 R280H [endoplasmic reticulum membrane]
(R-HSA-2471937)
RDH5 [endoplasmic reticulum membrane]
(R-HSA-74825)
0.488
2
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