TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP

Stable Identifier
R-HSA-6814833
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
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TBC1D20 was identified as a RAB1-specific GTPase activating protein (GAP) that stimulates RAB1-mediated GTP hydrolysis and plays roles in ER-to-Golgi trafficking. TBC1D20 is the only GAP that has been identified to block delivery of secretory cargo from the ER to the cell surface (Haas et al, 2007).
Literature References
PubMed ID Title Journal Year
17684057 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Haas, AK, Yoshimura, S, Stephens, DJ, Preisinger, C, Fuchs, E, Barr, FA

J. Cell. Sci. 2007
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Catalyst Activity

GTPase activity of RAB1:GTP:TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity
RAB1:GTP:TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Plasmodium falciparum)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Saccharomyces cerevisiae)
TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)
Authored
Rothfels, K  (2015-11-28)
Reviewed
Gillespie, ME  (2015-11-25)
Created
Rothfels, K  (2015-11-28)
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