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DSG4 [plasma membrane]
Stable Identifier
R-HSA-6814743
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmoglein-4, DSG4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmogelins [plasma membrane] (Homo sapiens)
DSG4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86SJ6 DSG4
Gene Names
DSG4, CDHF13
Chain
signal peptide:1-23, propeptide:24-49, chain:50-1040
Reference Genes
BioGPS Gene:147409 DSG4
COSMIC (genes):DSG4 DSG4
CTD Gene:147409 DSG4
dbSNP Gene:147409 DSG4
ENSEMBL:ENSG00000175065 DSG4
HGNC:21307 DSG4
Monarch:147409 DSG4
NCBI Gene:147409 DSG4
OMIM:607892 DSG4
UCSC:Q86SJ6 DSG4
Reference Transcript
RefSeq:NM_177986.4 DSG4
RefSeq:NM_001134453.2 DSG4
Other Identifiers
11734630_a_at
147409
1561330_PM_at
1561330_at
16851727
3783436
3783437
3783438
3783444
3783445
3783446
3783447
3783448
3783449
3783450
3783453
3783456
3783457
3783458
3783459
3783460
3783461
3783462
3783463
3783464
3783465
3783466
3783467
3783469
8020740
A_14_P133918
A_32_P538928
GE746997
GO:0001533
GO:0001942
GO:0005509
GO:0005886
GO:0007155
GO:0007156
GO:0016020
GO:0030057
GO:0030154
GO:0030216
GO:0030509
GO:0046872
GO:0048856
GO:0070161
GO:0098609
HMNXSV003024711
Hs2.407618.1.S1_3p_at
ILMN_1812799
PH_hs_0019428
TC18000125.hg
Participates
as a member of
Desmogelins [plasma membrane] (Homo sapiens)
Other forms of this molecule
DSG4 [cornified envelope]
Inferred To
Dsg4 [plasma membrane]
(Mus musculus)
Dsg4 [plasma membrane]
(Rattus norvegicus)
dsg2.1 [plasma membrane]
(Danio rerio)
DSG4 [plasma membrane]
(Bos taurus)
DSG4 [plasma membrane]
(Canis familiaris)
DSG4 [plasma membrane]
(Gallus gallus)
DSG4 [plasma membrane]
(Sus scrofa)
cdh-4 [plasma membrane]
(Caenorhabditis elegans)
dsg1 [plasma membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000352785
,
ENST00000359747
,
ENSP00000311859
,
ENST00000308128
OpenTargets
ENSG00000175065
HPA
ENSG00000175065-DSG4
PRO
Q86SJ6
Pharos - Targets
Q86SJ6
GlyGen
Q86SJ6
Orphanet
DSG4
HMDB Protein
HMDBP07661
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