Reactome | Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins

Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins

Stable Identifier

R-HSA-6814674

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB9 positive vesicles from the late endosomes are tethered at the trans-Golgi network (TGN) through interaction with the GARP complex, the TGN-specific Golgin GCC2 and a t-SNARE complex consisting of STX10, STX16 and VTI1A (Hayes et al, 2009; Derby et al, 2007; Reddy et al, 2006; Ganley et al, 2008; Perez-Victoria et al, 2009; Lombardi et al, 1993; Lieu et al, 2007; reviewed in Chia and Gleeson, 2014)

Literature References

PubMed ID	Title	Journal	Year
18195106	A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells Pfeffer, SR, Espinosa, E, Ganley, IG	J. Cell Biol.	2008
16885419	A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling Reddy, JV, Burguete, AS, Nottingham, RM, Sridevi, K, Pfeffer, SR, Ganley, IG	Mol. Biol. Cell	2006
18946081	Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi Brown, FC, Hayes, GL, Nottingham, RM, Barr, FA, Haas, AK, Pfeffer, SR	Mol. Biol. Cell	2009
25343031	Membrane tethering Chia, PZ, Gleeson, PA	F1000Prime Rep	2014
19620288	Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network Pérez-Victoria, FJ, Bonifacino, JS	Mol. Cell. Biol.	2009
8440258	Rab9 functions in transport between late endosomes and the trans Golgi network Pfeffer, SR, Riederer, MA, Soldati, T, Zerial, M, Goda, Y, Lombardi, D	EMBO J.	1993
17488291	The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure Derby, MC, Goud, B, Brown, D, Lieu, ZZ, Stow, JL, Gleeson, PA	Traffic	2007