Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins

Stable Identifier
Reaction [binding]
Homo sapiens
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RAB9 positive vesicles from the late endosomes are tethered at the trans-Golgi network (TGN) through interaction with the GARP complex, the TGN-specific Golgin GCC2 and a t-SNARE complex consisting of STX10, STX16 and VTI1A (Hayes et al, 2009; Derby et al, 2007; Reddy et al, 2006; Ganley et al, 2008; Perez-Victoria et al, 2009; Lombardi et al, 1993; Lieu et al, 2007; reviewed in Chia and Gleeson, 2014)
Literature References
PubMed ID Title Journal Year
18195106 A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

Pfeffer, SR, Espinosa, E, Ganley, IG

J. Cell Biol. 2008
16885419 A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling

Reddy, JV, Burguete, AS, Nottingham, RM, Sridevi, K, Pfeffer, SR, Ganley, IG

Mol. Biol. Cell 2006
18946081 Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi

Brown, FC, Hayes, GL, Nottingham, RM, Barr, FA, Haas, AK, Pfeffer, SR

Mol. Biol. Cell 2009
25343031 Membrane tethering

Chia, PZ, Gleeson, PA

F1000Prime Rep 2014
19620288 Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network

PĂ©rez-Victoria, FJ, Bonifacino, JS

Mol. Cell. Biol. 2009
8440258 Rab9 functions in transport between late endosomes and the trans Golgi network

Pfeffer, SR, Riederer, MA, Soldati, T, Zerial, M, Goda, Y, Lombardi, D

EMBO J. 1993
17488291 The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure

Derby, MC, Goud, B, Brown, D, Lieu, ZZ, Stow, JL, Gleeson, PA

Traffic 2007
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