Reactome | PXLP-K333-GADL1 decarboxylates CSA to HTAU

PXLP-K333-GADL1 decarboxylates CSA to HTAU

Stable Identifier

R-HSA-6814165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3-sulfino-L-alanine + H(+) => CO2 + hypotaurine

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PXLP-K333-GADL1 decarboxylates CSA to HTAU

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acidic amino acid decarboxylase GADL1 (GADL1) can decarboxylate acidic amino acids such as cysteine sulfinic acid (CSA) to form hypotaurine (HTAU) (Liu et al. 2012, 2013). The dimeric structure of the enzyme is inferred from studies of its mouse homolog (Raasakka et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
23038267	Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis Liu, P, Ge, X, Ding, H, Jiang, H, Christensen, BM, Li, J	J. Biol. Chem.	2012
22718265	Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases Liu, P, Torrens-Spence, MP, Ding, H, Christensen, BM, Li, J	Amino Acids	2013
29372909	Structure of the mouse acidic amino acid decarboxylase GADL1 Raasakka, A, Mahootchi, E, Winge, I, Luan, W, Kursula, P, Haavik, J	Acta Crystallogr F Struct Biol Commun	2018