Reactome | ADO oxidises 2AET to HTAU

ADO oxidises 2AET to HTAU

Stable Identifier

R-HSA-6814153

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cysteamine + O2 => H(+) + hypotaurine

ReviewStatus

5/5

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Cysteine metabolism to its sulfoxidation end-products is dependent upon two iron-dependent enzymes that are the only known mammalian thiol dioxygenases. These two thiol dioxygenases are cysteine dioxygenase (CDO) and 2-aminoethanethiol dioxygenase (ADO, cysteamine dioxygenase ). Both of these thiol dioxygenases are essential for hypotaurine and taurine biosynthesis. ADO adds molecular oxygen to the sulfhydryl group of 2-aminoethanethiol (2AET, cysteamine) to form the sulfinic acid hypotaurine (HTAU) (Dominy et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17581819	Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase Dominy, JE, Simmons, CR, Hirschberger, LL, Hwang, J, Coloso, RM, Stipanuk, MH	J. Biol. Chem.	2007