ADO oxidises 2AET to HTAU

Stable Identifier
R-HSA-6814153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cysteine metabolism to its sulfoxidation end-products is dependent upon two iron-dependent enzymes that are the only known mammalian thiol dioxygenases. These two thiol dioxygenases are cysteine dioxygenase (CDO) and 2-aminoethanethiol dioxygenase (ADO, cysteamine dioxygenase ). Both of these thiol dioxygenases are essential for hypotaurine and taurine biosynthesis. ADO adds molecular oxygen to the sulfhydryl group of 2-aminoethanethiol (2AET, cysteamine) to form the sulfinic acid hypotaurine (HTAU) (Dominy et al. 2007).
Literature References
PubMed ID Title Journal Year
17581819 Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase

Dominy, JE, Coloso, RM, Stipanuk, MH, Simmons, CR, Hirschberger, LL, Hwang, J

J. Biol. Chem. 2007
Participants
Participates
Catalyst Activity

cysteamine dioxygenase activity of ADO:Fe2+ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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