ADO oxidises 2AET to HTAU

Stable Identifier
R-HSA-6814153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cysteine metabolism to its sulfoxidation end-products is dependent upon two iron-dependent enzymes that are the only known mammalian thiol dioxygenases. These two thiol dioxygenases are cysteine dioxygenase (CDO) and 2-aminoethanethiol dioxygenase (ADO, cysteamine dioxygenase ). Both of these thiol dioxygenases are essential for hypotaurine and taurine biosynthesis. ADO adds molecular oxygen to the sulfhydryl group of 2-aminoethanethiol (2AET, cysteamine) to form the sulfinic acid hypotaurine (HTAU) (Dominy et al. 2007).

Literature References
PubMed ID Title Journal Year
17581819 Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase

Dominy, JE, Simmons, CR, Hirschberger, LL, Hwang, J, Coloso, RM, Stipanuk, MH

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteamine dioxygenase activity of ADO:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created