PDCL binds G-protein beta and TRiC/CCT

Stable Identifier
R-HSA-6814121
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PDCL (PhLP1), phosphorylated by the casein kinase II complex (CK2), simultaneously binds to the unfolded G-protein beta subunit and the TRiC/CCT chaperonin (Lukov et al. 2005, Lukov et al. 2006, Plimpton et al. 2015). Phosphorylation is not a prerequisite for PDCL binding to TRiC/CCT and the unfolded G-protein beta, but is necessary for PDCL-mediated release of folded G-protein beta from TRiC/CCT (Lukov et al. 2006).

Literature References
PubMed ID Title Journal Year
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, McLaughlin, JN, Hamm, HE, Willardson, BM

EMBO J. 2005
16717095 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex

Lukov, GL, Baker, CM, Ludtke, PJ, Hu, T, Carter, MD, Hackett, RA, Thulin, CD, Willardson, BM

J. Biol. Chem. 2006
25675501 Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

Plimpton, RL, Cuellar, J, Lai, CW, Aoba, T, Makaju, A, Franklin, S, Mathis, AD, Prince, JT, Carrascosa, JL, Valpuesta, JM, Willardson, BM

Proc. Natl. Acad. Sci. U.S.A. 2015
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