Two hybrid screening with human ARL1 as bait identified ARFIP2 as a novel ARL1:GTP-interacting partner (Van Valkenburgh et al, 2001). Interaction between ARFIP2 and ARL1 increases the amount of ARL1:GTP four-fold , although the significance of this is not clear (Van Vlakenburgh et al, 2001). ARFIP2 is also known to interact with RAC1 and to influence membrane ruffling (van Aelst et al, 1996; Tarricone et al, 2001)
Justin, N, Rittinger, K, Walker, PA, Xiao, B, Smerdon, SJ, Gamblin, SJ, Tarricone, C
Van Aelst, L, Joneson, T, Bar-Sagi, D
Sharer, JD, Zhu, X, Kahn, RA, Van Valkenburgh, H, Shern, JF
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