Reactome | ARL1:GTP binds ARFIP2

ARL1:GTP binds ARFIP2

Stable Identifier

R-HSA-6814094

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two hybrid screening with human ARL1 as bait identified ARFIP2 as a novel ARL1:GTP-interacting partner (Van Valkenburgh et al, 2001). Interaction between ARFIP2 and ARL1 increases the amount of ARL1:GTP four-fold , although the significance of this is not clear (Van Vlakenburgh et al, 2001). ARFIP2 is also known to interact with RAC1 and to influence membrane ruffling (van Aelst et al, 1996; Tarricone et al, 2001)

Literature References

PubMed ID	Title	Journal	Year
11346801	The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways Justin, N, Rittinger, K, Walker, PA, Xiao, B, Smerdon, SJ, Gamblin, SJ, Tarricone, C	Nature	2001
8670882	Identification of a novel Rac1-interacting protein involved in membrane ruffling Van Aelst, L, Joneson, T, Bar-Sagi, D	EMBO J.	1996
11303027	ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins Sharer, JD, Zhu, X, Kahn, RA, Van Valkenburgh, H, Shern, JF	J. Biol. Chem.	2001