ARL1 recruits TGN Golgin homodimers

Stable Identifier
Reaction [binding]
Homo sapiens
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GTP-bound ARL1, in conjunction with RAB6 and/or RAB9, is responsible for the recruitment of the 4 trans-Golgi network associated Golgin tethering factors, GOLGA4 (also known as Golgin245), GOLGA1 (also known as Golgin97), GCC1 (also known as GCC88) and GCC2 (also known as GCC185) (Barr et al, 1999; van Valkenburgh et al, 2001; Panic et al, 2003a; Panic et al, 2003b; Wu et al, 2004; Setty et al, 2003; reviewed in Munro et al, 2011). These coiled-coil tethering factors act as homodimers and participate in the recruitment of early endolysosomal-derived vesicles to the TGN by virtue of interacting with SNAREs and RAB proteins (Luke et al 2005; Lieu et al, 2007; Burguette et al, 2008; Ganley et al, 2008; Hayes et al, 2009; reviewed in Munro et al, 2011; Pfeffer, 2011). Evidence suggests that the Golgin tethering proteins show specificity for different retrograde cargos. For instance, retrograde transport of Shiga toxin requires both GOLGA1 and GOLGA4, while GOLGA1 is dispensible for transport of mannose-6-phosphate receptors (Lu et al, 2004; Yoshino et al, 2005; Reddy et al, 2006). Similarly, GCC1, but not GCC2, is required for TGN46 retrograde transport (Lieu et al, 2007; Derby et al, 2007). A fifth TGN-localized Golgin, TMF1, may also function similarly in retrograde transport from the early endosomes as it has been shown to interact with RAB6 and to be required for retrograde transport of Shiga toxin (Fridmann-Sirkis et al, 2004; Yamane et al, 2007).

Literature References
PubMed ID Title Journal Year
18195106 A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

Pfeffer, SR, Espinosa, E, Ganley, IG

J. Cell Biol. 2008
18946081 Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi

Brown, FC, Hayes, GL, Nottingham, RM, Barr, FA, Haas, AK, Pfeffer, SR

Mol. Biol. Cell 2009
8636227 A v-SNARE implicated in intra-Golgi transport

Söllner, TH, Ravazzola, M, Orci, L, Amherdt, M, Rothman, JE, Tempst, P, Nagahama, M, Lacomis, L

J. Cell Biol. 1996
18243103 Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185

Burguete, AS, Pfeffer, SR, Fenn, TD, Brunger, AT

Cell 2008
15654769 The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers

Luke, MR, Perugini, MA, Houghton, F, Gleeson, PA

Biochem. J. 2005
11303027 ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins

Sharer, JD, Zhu, X, Kahn, RA, Van Valkenburgh, H, Shern, JF

J. Biol. Chem. 2001
12620189 The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the Golgi apparatus

Panic, B, Whyte, JR, Munro, S

Curr. Biol. 2003
21421921 Entry at the trans-face of the Golgi

Pfeffer, SR

Cold Spring Harb Perspect Biol 2011
15269279 Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network

Hong, W, Tai, G, Lu, L

Mol. Biol. Cell 2004
21436057 The golgin coiled-coil proteins of the Golgi apparatus

Munro, S

Cold Spring Harb Perspect Biol 2011
16885419 A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling

Reddy, JV, Burguete, AS, Nottingham, RM, Sridevi, K, Pfeffer, SR, Ganley, IG

Mol. Biol. Cell 2006
12620188 Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3

Setty, SR, Marks, MS, Burd, CG, Shin, ME, Yoshino, A

Curr. Biol. 2003
14718928 Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1

Song, H, Hong, W, Wu, M, Lu, L

Nat. Struct. Mol. Biol. 2004
10209123 A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins

Barr, FA

Curr. Biol. 1999
15128430 TMF is a golgin that binds Rab6 and influences Golgi morphology

Pelham, HR, Fridmann-Sirkis, Y, Siniossoglou, S

BMC Cell Biol. 2004
17488291 The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure

Derby, MC, Goud, B, Brown, D, Lieu, ZZ, Stow, JL, Gleeson, PA

Traffic 2007
15870108 tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre

Poynton, C, Whiteman, EL, Setty, SR, Saint-Pol, A, Johannes, L, Holzbaur, EL, McCaffery, JM, Marks, MS, Burd, CG, Koval, M, Yoshino, A

J. Cell. Sci. 2005
17698061 Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic

Yamane, J, Tsukita, S, Kubo, A, Tsukita, S, Yuba-Kubo, A, Katsuno, T, Nakayama, K

Exp. Cell Res. 2007
14580338 Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus

Panic, B, Williams, RL, Veprintsev, DB, Munro, S, Perisic, O

Mol. Cell 2003
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