Reactome | SYS1 binds AcM-ARFRP1

SYS1 binds AcM-ARFRP1

Stable Identifier

R-HSA-6814088

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

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Acetylation of the N-terminal methionine of ARFRP1 contributes to its interaction with the Golgi-localized membrane protein SYS1. ARFRP1 is part of an ARF cascade at the late or trans-Golgi, where it plays a role in retrograde traffic by recruiting ARL1, which in turn interacts with a number of Golgin tethering factors required for vesicle docking at the TGN (Behnia et al, 2004; Setty et al, 2004; Shin et al, 2005; reviewed in Bonifacino and Rojas, 2006; Munro, 2011).

Literature References

PubMed ID	Title	Journal	Year
16936697	Retrograde transport from endosomes to the trans-Golgi network Rojas, R, Bonifacino, JS	Nat. Rev. Mol. Cell Biol.	2006
15077114	Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p Setty, SR, Boone, C, Tong, AH, Strochlic, TI, Burd, CG	Nat. Cell Biol.	2004
15077113	Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p Panic, B, Whyte, JR, Behnia, R, Munro, S	Nat. Cell Biol.	2004
16129887	Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking Uchiyama, Y, Kobayashi, H, Nakayama, K, Waguri, S, Kitamura, M, Suganuma, T, Shin, HW	J. Cell. Sci.	2005
21436057	The golgin coiled-coil proteins of the Golgi apparatus Munro, S	Cold Spring Harb Perspect Biol	2011