Reactome | ARFRP1 recruits ARL1 to the TGN

ARFRP1 recruits ARL1 to the TGN

Stable Identifier

R-HSA-6814086

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

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ARFRP1 regulates Golgi localization of ARL1, another ARF-like GTPase that itself recruits a number of Golgin-tethering factors to the TGN. Knockout strains of ARL3, the yeast homologue of ARFRP1, abrogates Golgi localization of both yeast Arl1p and the four yeast Golgin homologues, suggesting a cascade of ARL proteins is contributes to retrograde trafficking at the TGN (Setty et al, 2003; Setty et al, 2004; Behnia et al, 2004; Panic et al, 2003; reviewed in Munro, 2005; Bonafacino and Rojas, 2006). GEF and GAP proteins that regulate ARFRP1 and ARL1 activity have not yet been identified (reviewed in Munro, 2005).

Literature References

PubMed ID	Title	Journal	Year
12620188	Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3 Setty, SR, Marks, MS, Burd, CG, Shin, ME, Yoshino, A	Curr. Biol.	2003
16936697	Retrograde transport from endosomes to the trans-Golgi network Rojas, R, Bonifacino, JS	Nat. Rev. Mol. Cell Biol.	2006
15077114	Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p Setty, SR, Boone, C, Tong, AH, Strochlic, TI, Burd, CG	Nat. Cell Biol.	2004
15077113	Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p Panic, B, Whyte, JR, Behnia, R, Munro, S	Nat. Cell Biol.	2004
16042553	The Arf-like GTPase Arl1 and its role in membrane traffic Munro, S	Biochem. Soc. Trans.	2005
14580338	Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus Panic, B, Williams, RL, Veprintsev, DB, Munro, S, Perisic, O	Mol. Cell	2003