Reactome | ALDH1A1 oxidises GA to DGA

ALDH1A1 oxidises GA to DGA

Stable Identifier

R-HSA-6813749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH

ReviewStatus

5/5

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Retinal dehydrogenase 1 (ALDH1A1 tetramer) is a cytosolic aldehyde dehydrogenase that can oxidise glyceraldehyde (GA) to D-glycerate (DGA) (Yoval-Sanchez et al. 2013). DGA is a metabolite in a minor pathway of fructose catabolism and serine catabolism.

Literature References

PubMed ID	Title	Journal	Year
23444097	New insights into the half-of-the-sites reactivity of human aldehyde dehydrogenase 1A1 Rodriguez-Zavala, JS, Pardo, JP, Yoval-Sánchez, B	Proteins	2013