ALDH1A1 oxidises GA to DGA

Stable Identifier
R-HSA-6813749
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH
ReviewStatus
5/5
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ALDH1A1 oxidises GA to DGA
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Retinal dehydrogenase 1 (ALDH1A1 tetramer) is a cytosolic aldehyde dehydrogenase that can oxidise glyceraldehyde (GA) to D-glycerate (DGA) (Yoval-Sanchez et al. 2013). DGA is a metabolite in a minor pathway of fructose catabolism and serine catabolism.
Literature References
PubMed ID Title Journal Year
23444097 New insights into the half-of-the-sites reactivity of human aldehyde dehydrogenase 1A1

Yoval-Sánchez, B, Pardo, JP, Rodriguez-Zavala, JS

Proteins 2013
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as an event of
Catalyst Activity

aldehyde dehydrogenase (NAD+) activity of ALDH1A1 tetramer [cytosol]

Physical Entity
ALDH1A1 tetramer [cytosol] (Homo sapiens)
Activity
aldehyde dehydrogenase (NAD+) activity (GO:0004029)
Orthologous Events
ALDH1A1 oxidises GA to DGA (Bos taurus)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Mus musculus)
ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
ALDH1A1 oxidises GA to DGA (Sus scrofa)
ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-11-24)
Reviewed
D'Eustachio, P  (2016-01-11)
Hill, DP  (2023-05-16)
Created
Jassal, B  (2015-11-24)
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