Reactome | ELANE, CTSG or PRTN3 binds bacteria

ELANE, CTSG or PRTN3 binds bacteria

Stable Identifier

R-HSA-6813659

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Elastase, Proteinase 3, or Cathepsin G binds bacteria

ReviewStatus

5/5

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Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes that are rapidly recruited to sites of infection by host- and/or pathogen-derived components. PMNs provide the first-line defense against infection killing invading pathogens and resolving the inflammation they cause (Kobayashi SD et al. 2005). Activated neutrophils are known to release a variety of molecules, including the neutrophil serine proteases such as neutrophil elastase (ELINE), proteinase 3 (PRTN3) and cathepsin G (CTSG) (Garwicz D et al. 2005). Neutrophil serine proteases contribute to antimicrobial defense by

attacking membrane-associated (E. coli) or capsule proteins (S.pneumonia), which leads to loss of membrane integrity (Belaaouaj A et al. 2000; Standish AJ & Weiser JN 2009)
processing host immune proteins to generate antimicrobial peptides that can directly kill bacteria (Sorensen OE et al. 2001)
targeting and inactivating bacterial virulence factors to attenuate bacteria (Weinrauch Y et al. 2002; Lopez-Boado YS et al. 2004)

Literature References

PubMed ID	Title	Journal	Year
16799473	Neutrophil serine proteases: specific regulators of inflammation Pham, CT	Nat. Rev. Immunol.	2006
25461571	Neutrophil serine proteases in antibacterial defense Stapels, DA, Geisbrecht, BV, Rooijakkers, SH	Curr. Opin. Microbiol.	2015
18021746	Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions Moreau, T, Korkmaz, B, Gauthier, F	Biochimie	2008