Reactome | ING2-bound EP300 acetylates TP53

ING2-bound EP300 acetylates TP53

Stable Identifier

R-HSA-6811508

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        ING2-bound EP300 acetylates TP53 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The histone acetyltransferase EP300 (p300), recruited to TP53 (p53) by ING2, acetylates TP53 on lysine residue K382, which may contribute to TP53-dependent apoptosis (Padeux et al. 2005). PI5P positively regulates TP53 acetylation (Zou et al. 2007), possibly by increasing the amount of ING2 in the nucleus (Gozani et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
17940011	Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2007
12859901	The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor Ivanov, D, Jones, DR, Zhu, H, Baird, CL, Lessnick, SL, Gozani, O, Mehrotra, B, Prestwich, GD, Wagner, G, Myszka, DG, Ferguson, CG, Field, SJ, Cantley, LC, Lugovskoy, AA, Cha, J, Karuman, P, Payrastre, B, Brugge, JS, Yuan, J, Villasenor, J, Divecha, N, Rao, VR, Chen, J	Cell	2003
16024799	ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation McMenamin, M, Garfield, SH, Harris, CC, Shen, JC, Saito, S, Wincovitch, S, Grossman, SR, Sengupta, S, Appella, E, Kumamoto, K, Demidov, ON, Onogi, H, Pedeux, R, Nagashima, M	Mol. Cell. Biol.	2005