ING2-bound EP300 acetylates TP53

Stable Identifier
R-HSA-6811508
Type
Reaction
Species
Homo sapiens
Compartment
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The histone acetyltransferase EP300 (p300), recruited to TP53 (p53) by ING2, acetylates TP53 on lysine residue K382, which may contribute to TP53-dependent apoptosis (Padeux et al. 2005). PI5P positively regulates TP53 acetylation (Zou et al. 2007), possibly by increasing the amount of ING2 in the nucleus (Gozani et al. 2003).

Literature References
PubMed ID Title Journal Year
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J

Proc. Natl. Acad. Sci. U.S.A. 2007
12859901 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

Ivanov, D, Jones, DR, Zhu, H, Baird, CL, Lessnick, SL, Gozani, O, Mehrotra, B, Prestwich, GD, Wagner, G, Myszka, DG, Ferguson, CG, Field, SJ, Cantley, LC, Lugovskoy, AA, Cha, J, Karuman, P, Payrastre, B, Brugge, JS, Yuan, J, Villasenor, J, Divecha, N, Rao, VR, Chen, J

Cell 2003
16024799 ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation

McMenamin, M, Garfield, SH, Harris, CC, Shen, JC, Saito, S, Wincovitch, S, Grossman, SR, Sengupta, S, Appella, E, Kumamoto, K, Demidov, ON, Onogi, H, Pedeux, R, Nagashima, M

Mol. Cell. Biol. 2005
Participants
Participates
Catalyst Activity

peptide-lysine-N-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm]

This event is regulated
Positively by
Regulator
Orthologous Events
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