Reactome | ING2 recruits EP300 to TP53

ING2 recruits EP300 to TP53

Stable Identifier

R-HSA-6811479

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        ING2 recruits EP300 to TP53 (Homo sapiens)

General

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ING2 recruits histone acetyltransferase EP300 (p300) to TP53 (Padeux et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16024799	ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation McMenamin, M, Garfield, SH, Harris, CC, Shen, JC, Saito, S, Wincovitch, S, Grossman, SR, Sengupta, S, Appella, E, Kumamoto, K, Demidov, ON, Onogi, H, Pedeux, R, Nagashima, M	Mol. Cell. Biol.	2005