RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

Stable Identifier
Reaction [transition]
Homo sapiens
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The RIC1:RGP1 complex stimulates nucleotide exchange on trans-Golgi network (TGN)-localized RAB6, activating it (Pusapati et al, 2012; Siniossoglou et al 2001; Siniossoglou et al, 2000). Acitvated RAB6 nucleates a tethering complex at the TGN that is required for fusion of endosome-derived vesicles arriving at the late Golgi (Siniossoglou et al, 2001; Liewen et al, 2005; Perez-Victoria et al, 2008; Perez-Victoria et al, 2009; reviewed in Bonaficino and Hierro, 2011).
Literature References
PubMed ID Title Journal Year
18367545 Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes

Mardones, GA, Pérez-Victoria, FJ, Bonifacino, JS

Mol. Biol. Cell 2008
11689439 An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes

Pelham, HR, Siniossoglou, S

EMBO J. 2001
23091056 Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase

Pfeffer, SR, Luchetti, G, Pusapati, GV

J. Biol. Chem. 2012
19620288 Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network

Pérez-Victoria, FJ, Bonifacino, JS

Mol. Cell. Biol. 2009
10990452 Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p

Pelham, HR, Siniossoglou, S, Peak-Chew, SY

EMBO J. 2000
21183348 Transport according to GARP: receiving retrograde cargo at the trans-Golgi network

Hierro, A, Bonifacino, JS

Trends Cell Biol. 2011
15878329 Characterization of the human GARP (Golgi associated retrograde protein) complex

Schwarzenbacher, R, Jung, M, Liewen, H, Pfreundschuh, M, Meinhold-Heerlein, I, Oliveira, V, Luo, G, Wadle, A, Stenner-Liewen, F

Exp. Cell Res. 2005
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB6:GDP:RIC1:RGP1 [trans-Golgi network membrane]

Orthologous Events
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