Reactome | RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

Stable Identifier

R-HSA-6811429

Type

Reaction [transition]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

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RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

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The RIC1:RGP1 complex stimulates nucleotide exchange on trans-Golgi network (TGN)-localized RAB6, activating it (Pusapati et al, 2012; Siniossoglou et al 2001; Siniossoglou et al, 2000). Acitvated RAB6 nucleates a tethering complex at the TGN that is required for fusion of endosome-derived vesicles arriving at the late Golgi (Siniossoglou et al, 2001; Liewen et al, 2005; Perez-Victoria et al, 2008; Perez-Victoria et al, 2009; reviewed in Bonaficino and Hierro, 2011).

Literature References

PubMed ID	Title	Journal	Year
18367545	Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes Pérez-Victoria, FJ, Mardones, GA, Bonifacino, JS	Mol. Biol. Cell	2008
11689439	An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes Siniossoglou, S, Pelham, HR	EMBO J.	2001
23091056	Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase Pusapati, GV, Luchetti, G, Pfeffer, SR	J. Biol. Chem.	2012
19620288	Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network Pérez-Victoria, FJ, Bonifacino, JS	Mol. Cell. Biol.	2009
10990452	Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p Siniossoglou, S, Peak-Chew, SY, Pelham, HR	EMBO J.	2000
21183348	Transport according to GARP: receiving retrograde cargo at the trans-Golgi network Bonifacino, JS, Hierro, A	Trends Cell Biol.	2011
15878329	Characterization of the human GARP (Golgi associated retrograde protein) complex Liewen, H, Meinhold-Heerlein, I, Oliveira, V, Schwarzenbacher, R, Luo, G, Wadle, A, Jung, M, Pfreundschuh, M, Stenner-Liewen, F	Exp. Cell Res.	2005