Reactome | Retrograde COPI vesicles bind kinesin and microtubules

Retrograde COPI vesicles bind kinesin and microtubules

Stable Identifier

R-HSA-6811426

Type

Reaction [binding]

Species

Homo sapiens

Compartment

transport vesicle

ReviewStatus

5/5

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Retrograde COPI vesicles bind kinesin and microtubules

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COPI-mediated retrograde traffic is dependent on microtubules and the plus-end motor kinsesin. Although it is not shown in this reaction, vesicle translocation along the microtubules by kinesin depends on ATP hydrolysis (Lippincott-Scwartz et al, 1995; Stauber et al, 2006; Tomas et al, 2010)

Literature References

PubMed ID	Title	Journal	Year
7844144	Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic Bloom, GS, Lippincott-Schwartz, J, Cole, NB, Marotta, A, Conrad, PA	J. Cell Biol.	1995
17113389	A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex Simpson, JC, Pepperkok, R, Stauber, T, Vernos, I	Curr. Biol.	2006
20136777	Regulation of ER-Golgi intermediate compartment tubulation and mobility by COPI coats, motor proteins and microtubules Tomás, M, Martínez-Alonso, E, Ballesta, J, Martínez-Menárguez, JA	Traffic	2010