GBF1 stimulates nucleotide exchange on ARF

Stable Identifier
Reaction [transition]
Homo sapiens
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GBF1 facilitates the exchange of GDP for GTP, activating ARF (Niu et al, 2005; Szul et al, 2005; Szul et al, 2007; Kawamoto et al, 2002; reviewed in Szul and Sztul, 2011).

Literature References
PubMed ID Title Journal Year
15616190 Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi

Niu, TK, Pfeifer, AC, Lippincott-Schwartz, J, Jackson, CL

Mol. Biol. Cell 2005
12047556 GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat

Kawamoto, K, Yoshida, Y, Tamaki, H, Torii, S, Shinotsuka, C, Yamashina, S, Nakayama, K

Traffic 2002
22013193 COPII and COPI traffic at the ER-Golgi interface

Szul, T, Sztul, E

Physiology (Bethesda) 2011
15813748 Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1

Szul, T, Garcia-Mata, R, Brandon, E, Shestopal, S, Alvarez, C, Sztul, E

Traffic 2005
17956946 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking

Szul, T, Grabski, R, Lyons, S, Morohashi, Y, Shestopal, S, Lowe, M, Sztul, E

J. Cell. Sci. 2007
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB1:GTP:GBF1:ARF:GDP [Golgi membrane]

Orthologous Events
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