Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
EVPL [cytosol]
Stable Identifier
R-HSA-6810853
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Envoplakin, EVPL_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Envoplakin binds periplakin (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL:Cell surface [plasma membrane] (Homo sapiens)
EVPL:PPL [cytosol] (Homo sapiens)
EVPL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92817 EVPL
Gene Names
EVPL
Chain
chain:1-2033
Reference Genes
BioGPS Gene:2125 EVPL
COSMIC (genes):EVPL EVPL
CTD Gene:2125 EVPL
dbSNP Gene:2125 EVPL
ENSEMBL:ENSG00000167880 EVPL
ENSEMBL_homo_sapiens_GENE:ENSG00000167880.8 EVPL
HGNC:3503 EVPL
KEGG Gene (Homo sapiens):2125 EVPL
Monarch:2125 EVPL
NCBI Gene:2125 EVPL
OMIM:601590 EVPL
UCSC:Q92817 EVPL
Reference Transcript
RefSeq:NM_001320747.1 EVPL
RefSeq:NM_001988.3 EVPL
Other Identifiers
11726123_a_at
16849047
204503_PM_at
204503_at
2125
3713230
3713236
3713238
3713239
3771261
3771262
3771263
3771264
3771265
3771266
3771268
3771269
3771270
3771272
3771273
3771274
3771275
3771276
3771277
3771278
3771279
3771280
3771281
3771282
3771283
3771284
3771285
3771286
3771287
3771288
3771289
3771291
3771292
39569_at
8018579
A_24_P104512
GE81099
GO:0001533
GO:0002376
GO:0002786
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0005886
GO:0007010
GO:0008544
GO:0016020
GO:0018149
GO:0030057
GO:0030154
GO:0030216
GO:0031424
GO:0036211
GO:0042060
GO:0043226
GO:0045104
GO:0045111
GO:0045296
GO:0048856
GO:0070062
GO:0070161
GO:0098542
HMNXSV003021421
ILMN_1727288
PH_hs_0026157
TC17001891.hg
U53786_at
g4503612_3p_at
Participates
as an input of
Envoplakin binds periplakin (Homo sapiens)
as a component of
EVPL:PPL [cytosol] (Homo sapiens)
Other forms of this molecule
EVPL [cornified envelope]
Inferred To
evpl [cytosol]
(Xenopus tropicalis)
EVPL [cytosol]
(Bos taurus)
EVPL [cytosol]
(Canis familiaris)
EVPL [cytosol]
(Gallus gallus)
EVPL [cytosol]
(Sus scrofa)
Evpl [cytosol]
(Mus musculus)
Evpl [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001307676.1
,
NP_001979.2
OpenTargets
ENSG00000167880
GeneCards
Q92817
HPA
ENSG00000167880-EVPL
Ensembl
ENSG00000167880
,
ENSP00000301607
,
ENST00000301607
PRO
Q92817
Pharos - Targets
Q92817
PDB
4QMD
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text