NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

Stable Identifier
R-HSA-6810474
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Coenzyme A (CoA-SH) and acyl-coenzyme A (acyl-CoA) can be degraded in peroxisomes by two members of the Nudix (nucleoside diphosphates linked to some moiety X) hydrolase superfamily; NUDT7 and NUDT19. NUDT19 hydrolyses free fatty acyl-CoA to form acyl-phosphopantetheine (acyl-PPANT) and 3′,5′-ADP. Human NUDT19 activity is inferred from mouse Nudt19 activity (Ofman et al. 2006).

Literature References
PubMed ID Title Journal Year
16185196 Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity

Ofman, R, Speijer, D, Leen, R, Wanders, RJ

Biochem. J. 2006
Participants
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Catalyst Activity
Catalyst Activity
Title
acyl-CoA hydrolase activity of NUDT19 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
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