Reactome | NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

Stable Identifier

R-HSA-6810474

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Coenzyme A (CoA-SH) and acyl-coenzyme A (acyl-CoA) can be degraded in peroxisomes by two members of the Nudix (nucleoside diphosphates linked to some moiety X) hydrolase superfamily; NUDT7 and NUDT19. NUDT19 hydrolyses free fatty acyl-CoA to form acyl-phosphopantetheine (acyl-PPANT) and 3′,5′-ADP. Human NUDT19 activity is inferred from mouse Nudt19 activity (Ofman et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16185196	Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity Speijer, D, Leen, R, Wanders, RJA, Ofman, R	Biochem. J.	2006