NUDT13 hydrolyses AP6A to AP4 and ADP

Stable Identifier
R-HSA-6810472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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NUDT13 hydrolyses AP6A to AP4 and ADP
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Mitochondrial Nudix hydrolase 13 (NUDT13) is able to hydrolyse long-chain diadenosine polyphosphates such as diadenosine hexaphosphate (AP6A) to ADP and adenosine tetraphosphate (AP4). Human NUDT13 activity is inferred from Nudt13 activity in Arabidopsis thaliana (Olejnik et al. 2007). Diadenosine polyphosphates play a role in the cardiovascular system with potential involvement in mediating the pathophysiological effects associated with platelet activation during myocardial ischaemia.

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Catalyst Activity

pyrophosphatase activity of NUDT13 [mitochondrial matrix]

Physical Entity
NUDT13 [mitochondrial matrix] (Homo sapiens)
Activity
pyrophosphatase activity (GO:0016462)
Orthologous Events
NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)
NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)
NUDT13 hydrolyses AP6A to AP4 and ADP (Danio rerio)
NUDT13 hydrolyses AP6A to AP4 and ADP (Gallus gallus)
NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)
NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)
NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)
NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-11-17)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-11-17)
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