ING2 binds PI5P

Stable Identifier
R-HSA-6810376
Type
Reaction
Species
Homo sapiens
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The PHD finger of ING2 binds phosphatidylinositol-5-phosphate (PI5P) (Gozani et al. 2003), which promotes nuclear retention of ING2 (Jones et al. 2006, Zou et al. 2007).

Literature References
PubMed ID Title Journal Year
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J

Proc. Natl. Acad. Sci. U.S.A. 2007
16949365 Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta

Jones, DR, D'Santos, CS, Bultsma, Y, Heck, AJ, Keune, WJ, Halstead, JR, Divecha, N, Mohammed, S, Elouarrat, D

Mol. Cell 2006
12859901 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

Ivanov, D, Jones, DR, Zhu, H, Baird, CL, Lessnick, SL, Gozani, O, Mehrotra, B, Prestwich, GD, Wagner, G, Myszka, DG, Ferguson, CG, Field, SJ, Cantley, LC, Lugovskoy, AA, Cha, J, Karuman, P, Payrastre, B, Brugge, JS, Yuan, J, Villasenor, J, Divecha, N, Rao, VR, Chen, J

Cell 2003
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