SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

Stable Identifier
R-HSA-6810239
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Transcription factors at the distal sequence element (DSE) recruit the SNAPc complex to bind the proximal sequence element (PSE) (Sadowski et al. 1993, Henry et al. 1995, Mittal et al. 1996, Ford and Hernandez 1997, Ford et al. 1998, Hovde et al. 2002, Jawdekar et al. 2006, James Faresse et al. 2012). Binding of SNAPc distinguishes snRNA promoters from promoters of mRNA-encoding genes, which have TATA or other elements rather than PSEs (Henry et al. 1995).

Literature References
PubMed ID Title Journal Year
8628262 The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc

Mittal, V, Cleary, MA, Herr, W, Hernandez, N

Mol. Cell. Biol. 1996
11856838 Crystallization of the Oct-1/SNAP190 peptide/DNA complex

Hovde, S, Brooks, A, Strong, K, Geiger, JH

Acta Crystallogr. D Biol. Crystallogr. 2002
12414730 Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex

Hovde, S, Hinkley, CS, Strong, K, Brooks, A, Gu, L, Henry, RW, Geiger, J

Genes Dev. 2002
16901896 The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC

Jawdekar, GW, Hanzlowsky, A, Hovde, SL, Jelencic, B, Feig, M, Geiger, JH, Henry, RW

J. Biol. Chem. 2006
9188510 Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA

Ford, E, Hernandez, N

J. Biol. Chem. 1997
7715707 A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III

Henry, RW, Sadowski, CL, Kobayashi, R, Hernandez, N

Nature 1995
8339931 Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE

Sadowski, CL, Henry, RW, Lobo, SM, Hernandez, N

Genes Dev 1993
23166507 Genomic study of RNA polymerase II and III SNAPc-bound promoters reveals a gene transcribed by both enzymes and a broad use of common activators

James Faresse, N, Canella, D, Praz, V, Michaud, J, Romascano, D, Hernandez, N

PLoS Genet. 2012
9832505 The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1

Ford, E, Strubin, M, Hernandez, N

Genes Dev. 1998
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