Reactome | SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

Stable Identifier

R-HSA-6810239

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

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Transcription factors at the distal sequence element (DSE) recruit the SNAPc complex to bind the proximal sequence element (PSE) (Sadowski et al. 1993, Henry et al. 1995, Mittal et al. 1996, Ford and Hernandez 1997, Ford et al. 1998, Hovde et al. 2002, Jawdekar et al. 2006, James Faresse et al. 2012). Binding of SNAPc distinguishes snRNA promoters from promoters of mRNA-encoding genes, which have TATA or other elements rather than PSEs (Henry et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
11856838	Crystallization of the Oct-1/SNAP190 peptide/DNA complex Hovde, S, Brooks, A, Strong, K, Geiger, JH	Acta Crystallogr. D Biol. Crystallogr.	2002
8628262	The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc Mittal, V, Cleary, MA, Herr, W, Hernandez, N	Mol. Cell. Biol.	1996
12414730	Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex Hovde, S, Hinkley, CS, Strong, K, Brooks, A, Gu, L, Henry, RW, Geiger, J	Genes Dev.	2002
16901896	The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC Jawdekar, GW, Hanzlowsky, A, Hovde, SL, Jelencic, B, Feig, M, Geiger, JH, Henry, RW	J. Biol. Chem.	2006
9188510	Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA Ford, E, Hernandez, N	J. Biol. Chem.	1997
7715707	A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III Henry, RW, Sadowski, CL, Kobayashi, R, Hernandez, N	Nature	1995
8339931	Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE Sadowski, CL, Henry, RW, Lobo, SM, Hernandez, N	Genes Dev	1993
23166507	Genomic study of RNA polymerase II and III SNAPc-bound promoters reveals a gene transcribed by both enzymes and a broad use of common activators James Faresse, N, Canella, D, Praz, V, Michaud, J, Romascano, D, Hernandez, N	PLoS Genet.	2012
9832505	The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1 Ford, E, Strubin, M, Hernandez, N	Genes Dev.	1998