RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The protein phosphatase RPAP2 binds RNA polymerase II phosphorylated at serine-7 of the C-terminal domain (CTD) (Egloff et al. 2012). RPRD1A and RPRD1B bind RNA polymerase II with RPAP2 and appear to act as scaffolds for the complex (Ni et al. 2011, Ni et al. 2014).

Literature References
PubMed ID Title Journal Year
22137580 Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes

Laitem, C, Murphy, S, Kiss, T, Zaborowska, J, Egloff, S

Mol. Cell 2012
24997600 RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

Mosley, AL, Young, P, Li, J, Murphy, S, Olsen, JB, Zhong, G, He, H, Hunter, GO, Emili, A, Huang, H, Xu, C, Senisterra, GA, Min, J, Ni, Z, Kuo, WH, Guo, X, Greenblatt, JF, Loppnau, P, Arrowsmith, CH, Guo, H, Marcon, E, Tempel, W, Wan, C, El Bakkouri, M, Kuznetsova, OV, Sidhu, SS

Nat. Struct. Mol. Biol. 2014
22231121 Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B

Guo, H, Marcon, E, Young, P, Li, J, Ruan, ED, Olsen, JB, Emili, A, Zhong, G, Ni, Z, Moffat, J, Guo, X, Greenblatt, JF

Transcription 2011
Orthologous Events
Cite Us!