General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene

Stable Identifier
R-HSA-6810234
Type
Reaction [binding]
Species
Homo sapiens
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The promoter of an snRNA gene binds the basal transcription factors TFIIA, TFIIB (GTF2B), TFIIE, and TFIIF (Bernues et al. 1993, Kuhlman et al. 1999). Rather than the TFIID complex found at promoters of mRNA-encoding genes, a unique complex containing TBP (Sadowski et al. 1993) and snTAFc is present at promoters of snRNA genes (Zaborowska et al. 2012). The P-TEFb complex is also observed at snRNA genes, however, it seems to play a role more in 3' processing than in elongation (Medlin et al. 2005). CDK7 is also present and phosphorylates the C-terminal domain of RNA polymerase II (Glover-Cutter et al. 2009).

Literature References
PubMed ID Title Journal Year
16308568 P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

Medlin, J, Scurry, A, Taylor, A, Zhang, F, Peterlin, BM, Murphy, S

EMBO J. 2005
19667075 TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II

Glover-Cutter, K, Larochelle, S, Erickson, B, Zhang, C, Shokat, K, Fisher, RP, Bentley, DL

Mol. Cell. Biol. 2009
8253082 Common and unique transcription factor requirements of human U1 and U6 snRNA genes

Bernu├ęs, J, Simmen, KA, Lewis, JD, Gunderson, SI, Polycarpou-Schwarz, M, Moncollin, V, Egly, JM, Mattaj, IW

EMBO J. 1993
22441827 A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes

Zaborowska, J, Taylor, A, Roeder, RG, Murphy, S

Transcription 2012
8339931 Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE

Sadowski, CL, Henry, RW, Lobo, SM, Hernandez, N

Genes Dev 1993
10022900 The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter

Kuhlman, TC, Cho, H, Reinberg, D, Hernandez, N

Mol. Cell. Biol. 1999
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