Reactome | General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene

Stable Identifier

R-HSA-6810234

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene

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The promoter of an snRNA gene binds the basal transcription factors TFIIA, TFIIB (GTF2B), TFIIE, and TFIIF (Bernues et al. 1993, Kuhlman et al. 1999). Rather than the TFIID complex found at promoters of mRNA-encoding genes, a unique complex containing TBP (Sadowski et al. 1993) and snTAFc is present at promoters of snRNA genes (Zaborowska et al. 2012). The P-TEFb complex is also observed at snRNA genes, however, it seems to play a role more in 3' processing than in elongation (Medlin et al. 2005). CDK7 is also present and phosphorylates the C-terminal domain of RNA polymerase II (Glover-Cutter et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19667075	TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II Glover-Cutter, K, Larochelle, S, Erickson, B, Zhang, C, Shokat, K, Fisher, RP, Bentley, DL	Mol. Cell. Biol.	2009
16308568	P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes Medlin, J, Scurry, A, Taylor, A, Zhang, F, Peterlin, BM, Murphy, S	EMBO J.	2005
8253082	Common and unique transcription factor requirements of human U1 and U6 snRNA genes Bernués, J, Simmen, KA, Lewis, JD, Gunderson, SI, Polycarpou-Schwarz, M, Moncollin, V, Egly, JM, Mattaj, IW	EMBO J.	1993
22441827	A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes Zaborowska, J, Taylor, A, Roeder, RG, Murphy, S	Transcription	2012
8339931	Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE Sadowski, CL, Henry, RW, Lobo, SM, Hernandez, N	Genes Dev	1993
10022900	The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter Kuhlman, TC, Cho, H, Reinberg, D, Hernandez, N	Mol. Cell. Biol.	1999