Reactome | NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Stable Identifier

R-HSA-6809354

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

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NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

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Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (NUDT7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels. Human NUDT7 activity is inferred from mouse Nudt7 activity (Gasmi et al. 2001, Reilly et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11415433	The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives Gasmi, L, McLennan, AG	Biochem. J.	2001
18799520	The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis Reilly, SJ, Tillander, V, Ofman, R, Alexson, SE, Hunt, MC	J. Biochem.	2008