NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Stable Identifier
R-HSA-6809354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (NUDT7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels. Human NUDT7 activity is inferred from mouse Nudt7 activity (Gasmi et al. 2001, Reilly et al. 2008).

Literature References
PubMed ID Title Journal Year
11415433 The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives

Gasmi, L, McLennan, AG

Biochem. J. 2001
18799520 The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis

Reilly, SJ, Tillander, V, Ofman, R, Alexson, SE, Hunt, MC

J. Biochem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CoA hydrolase activity of NUDT7 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
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