NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Stable Identifier
R-HSA-6809354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (NUDT7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels. Human NUDT7 activity is inferred from mouse Nudt7 activity (Gasmi et al. 2001, Reilly et al. 2008).
Literature References
PubMed ID Title Journal Year
18799520 The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis

Reilly, SJ, Alexson, SE, Tillander, V, Hunt, MC, Ofman, R

J. Biochem. 2008
11415433 The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives

Gasmi, L, McLennan, AG

Biochem. J. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

coenzyme A diphosphatase activity of NUDT7 [peroxisomal matrix]

Physical Entity
NUDT7 [peroxisomal matrix] (Homo sapiens)
Activity
coenzyme A diphosphatase activity (GO:0010945)
Inferred From
Nudt7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Mus musculus)
Cross References
RHEA
Rhea
Authored
Jassal, B  (2015-11-11)
Reviewed
D'Eustachio, P  (2016-01-11)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2015-11-11)
Cite Us!