Reactome | TMED9 [transport vesicle]

TMED9 [transport vesicle]

Stable Identifier

R-HSA-6808878

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

p25, GP25L2, Transmembrane emp24 domain-containing protein 9, GMP25, Glycoprotein 25L2, p24 family protein alpha-2, p24alpha2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED9 dimer [transport vesicle] (Homo sapiens)
        
        TMED9 [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BVK6 TMED9

Gene Names

TMED9, GP25L2

Chain

signal peptide:1-37, chain:38-235

Reference Genes

BioGPS Gene:54732 TMED9

COSMIC (genes):TMED9 TMED9

CTD Gene:54732 TMED9

dbSNP Gene:54732 TMED9

ENSEMBL:ENSG00000184840 TMED9

ENSEMBL_homo_sapiens_GENE:ENSG00000184840.12 TMED9

HGNC:24878 TMED9

KEGG Gene (Homo sapiens):54732 TMED9

Monarch:54732 TMED9

NCBI Gene:54732 TMED9

OMIM:620436 TMED9

UCSC:Q9BVK6 TMED9

Reference Transcript

RefSeq:NM_017510.5 TMED9

Other Identifiers

11716248_a_at

11716249_x_at

16993127

205812_PM_s_at

205812_s_at

208757_PM_at

208757_at

239627_PM_at

239627_at

2843268

2843269

2843272

2843273

2843275

2843278

2843279

2843280

2843281

2843282

2843329

2843331

2843332

2843334

2843337

2843338

2843339

2843340

2843341

36950_at

54732

8110392

87077_at

88063_s_at

A_23_P70127

GE541533

GE85552

GO:0000139

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006886

GO:0006888

GO:0007030

GO:0008021

GO:0010638

GO:0015031

GO:0016020

GO:0016192

GO:0019905

GO:0030133

GO:0030134

GO:0030140

GO:0031410

GO:0033116

GO:0043226

GO:0048205

GO:0061024

GO:0070062

HMNXSV003024541

Hs.211296.0.A1_3p_at

Hs.211296.0.A1_3p_x_at

ILMN_1743655

PH_hs_0027342

TC05001018.hg

X90872_at

g12654574_3p_at

g12654574_3p_s_at

Participates

as a component of

TMED9 dimer [transport vesicle] (Homo sapiens)

Other forms of this molecule

TMED9 [endoplasmic reticulum membrane]

TMED9 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TMED9 [Golgi membrane]

Inferred To

Homologues of TMED9 [transport vesicle] (Plasmodium falciparum)

Homologues of TMED9 [transport vesicle] (Saccharomyces cerevisiae)

ERP6 [transport vesicle] (Saccharomyces cerevisiae)

ERP1 [transport vesicle] (Saccharomyces cerevisiae)

tmed9 [transport vesicle] (Danio rerio)

tmed9 [transport vesicle] (Xenopus tropicalis)

Ghost homologue of TMED9 [transport vesicle] (Caenorhabditis elegans)

Ghost homologue of TMED9 [transport vesicle] (Drosophila melanogaster)

Ghost homologue of TMED9 [transport vesicle] (Gallus gallus)

Tmed9 [transport vesicle] (Mus musculus)

Tmed9 [transport vesicle] (Rattus norvegicus)

empC [transport vesicle] (Dictyostelium discoideum)

ERP5 [transport vesicle] (Saccharomyces cerevisiae)

TMED9 [transport vesicle] (Bos taurus)

TMED9 [transport vesicle] (Canis familiaris)

TMED9 [transport vesicle] (Plasmodium falciparum)

TMED9 [transport vesicle] (Schizosaccharomyces pombe)

TMED9 [transport vesicle] (Sus scrofa)

Cross References

RefSeq

NP_059980.2

OpenTargets

ENSG00000184840

GeneCards

Q9BVK6

HPA

ENSG00000184840-TMED9

Ensembl

ENSP00000330945, ENST00000332598, ENSG00000184840

PRO

Q9BVK6

Pharos - Targets

Q9BVK6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [Golgi membrane] (R-HSA-6808804) TMED2 [transport vesicle] (R-HSA-6808806)	0.643	3
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:P04618 rev	3	REV (P04618) protein [extracellular region] (R-HIV-174998) REV (P04618) protein [nucleoplasm] (R-HIV-175380) REV (P04618) protein [cytosol] (R-HIV-173267)	0.462	2

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