Reactome | TMED7 [Golgi membrane]

TMED7 [Golgi membrane]

Stable Identifier

R-HSA-6808810

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Transmembrane emp24 domain-containing protein 7, p24 family protein gamma-3, p24gamma3, p27

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        p24 dimers [Golgi membrane] (Homo sapiens)
        
        TMED7 dimer [Golgi membrane] (Homo sapiens)
        
        TMED7 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3B3 TMED7

Gene Names

TMED7, CGI-109

Chain

signal peptide:1-34, chain:35-224

Reference Genes

BioGPS Gene:100302736 TMED7

BioGPS Gene:51014 TMED7

COSMIC (genes):TMED7 TMED7

CTD Gene:100302736 TMED7

CTD Gene:51014 TMED7

dbSNP Gene:100302736 TMED7

dbSNP Gene:51014 TMED7

ENSEMBL:ENSG00000134970.14 TMED7

HGNC:24253 TMED7

KEGG Gene (Homo sapiens):100302736 TMED7

KEGG Gene (Homo sapiens):51014 TMED7

Monarch:100302736 TMED7

Monarch:51014 TMED7

NCBI Gene:100302736 TMED7

NCBI Gene:51014 TMED7

OMIM:619990 TMED7

UCSC:Q9Y3B3 TMED7

Reference Transcript

Other Identifiers

11725311_s_at

11725312_a_at

11725313_s_at

11752760_a_at

16999017

209404_PM_s_at

209404_s_at

214658_PM_at

214658_at

2871853

2871854

2871855

2871856

2871857

2871858

2871859

2871860

2871861

2871862

2871863

2871864

2871865

2871866

2871867

2871868

2871869

2871870

2871871

38500_at

51014

56404_at

8113623

A_24_P331727

A_32_P123088

GE540077

GE731159

GE818806

GE87714

GO:0000139

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006886

GO:0006888

GO:0007030

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030126

GO:0030127

GO:0030133

GO:0030134

GO:0030663

GO:0031410

GO:0033116

GO:0043226

HMNXSV003004996

Hs.278391.1.S1_3p_a_at

Hs.278391.1.S1_3p_x_at

ILMN_2186482

PH_hs_0015708

PH_hs_0032440

Participates

as a component of

TMED7 dimer [Golgi membrane] (Homo sapiens)

Other forms of this molecule

TMED7 [endoplasmic reticulum membrane]

TMED7 [transport vesicle]

TMED7 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Inferred To

Tmed7 [Golgi membrane] (Mus musculus)

Tmed7 [Golgi membrane] (Rattus norvegicus)

tmed-3 [Golgi membrane] (Caenorhabditis elegans)

EMP24 [Golgi membrane] (Saccharomyces cerevisiae)

empB [Golgi membrane] (Dictyostelium discoideum)

TMED7 [Golgi membrane] (Bos taurus)

TMED7 [Golgi membrane] (Canis familiaris)

TMED7 [Golgi membrane] (Gallus gallus)

TMED7 [Golgi membrane] (Plasmodium falciparum)

TMED7 [Golgi membrane] (Sus scrofa)

p24-1 [Golgi membrane] (Drosophila melanogaster)

tmed7 [Golgi membrane] (Xenopus tropicalis)

zgc:76996 [Golgi membrane] (Danio rerio)

emp24 [Golgi membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_861974.1, NP_001157941.1

OpenTargets

ENSG00000134970

GeneCards

Q9Y3B3

HPA

ENSG00000134970-TMED7

Ensembl

ENSG00000134970, ENSP00000405926, ENST00000456936

PRO

Q9Y3B3

Pharos - Targets

Q9Y3B3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15363 TMED2	5	TMED2 [Golgi membrane] (R-HSA-6808804) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531)	0.643	3

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